摘要
目的探讨乌司他丁联合异甘草酸镁对人肝脏缺血再灌注损伤的保护作用。方法选取60例需行肝叶切除手术的患者,随机分为对照组(单用乌司他丁)28例和试验组(乌司他丁联用异甘草酸镁)32例。观察术前及术后1 d、3 d、7 d两组谷丙转氨酶(ALT)、谷草转氨酶(AST)、血浆丙二醛(MDA)和超氧化物岐化酶(SOD)水平。结果术后l d、3 d、7 d,联用组与对照组在ALT、AST、MDA、SOD水平上差异均具有统计学差异(P<0.05)。结论乌司他丁联合异甘草酸镁对人肝脏缺血再灌注损伤具有明显的协同保护作用。
Objective To investgate the protective effect of Ulinastatin combined with Magnesium Isoglycyrrhizinate in the treatment of human hepatic ischemia-reperfusion injury.Methods Sixty patients underwent liver resection surgery were selected and randomly divided into two groups.The study group includes 32 patients received Ulinastatin combined with Magnesium Isoglycyrrhizinate,and the other 28 patients received only Ulinastatin were treated as the control group.The ALT,AST,plasma malondialdehyde（MDA） and superoxide dismutase（SOD） levels were collected preoperatively and 1 d,3 d and 7 d postoeratively in both groups.Results No significant differences were found in the ALT,AST,MDA and SOD levels preoperatively between the two groups.Compared with control group,the study group showed significantly ALT,AST,MDA and SOD levels decreased postoperative 1 d,3 d and 7 d（P0.05 for each group）.Conclusion Ulinastatin combined with Magnesium Isoglycyrrhizinate have an synergistic effect to treat human hepatic ischemia-reperfusion injury.
出处
《肝胆胰外科杂志》
CAS
2010年第5期375-377,共3页
Journal of Hepatopancreatobiliary Surgery
关键词
肝脏
缺血再灌注损伤
乌司他丁
异甘草酸镁
liver ischmia reperfused injury Ulinastatin Magnesium Isoglycyrrhizinate
