摘要
目的调查1998年8月～12月广州市12家医院临床分离常见病原菌对常用抗菌药物的耐药性。方法采用纸片扩散法测定20种抗菌素对临床分离983株革兰阴性菌和10种抗生素对472株革兰阳性球菌的药敏。结果确定了19种抗生素对肠杆菌科细菌敏感性顺序，各医院肠杆菌科细菌ESBLs平均检出率为40．7％～45．7％，并确定了治疗多种病原菌的最佳抗菌药物，未检出对万古霉素耐药的萄萄球菌。耐甲氧基青霉素的金葡蓖（MRSA）和凝固酶阴性葡萄球菌（MRCN）的检出分别为45．3％和64．1％。结论与国内外多中心耐药性监测结果相比较，本地区耐药情况较严重。亚胺硫霉素和万古霉素分别为治疗革兰阴性杆菌和革兰阳性球菌的最佳选药。
Objective Surveillance of resistance of common pathogenic bacteria isolated from twelve hos-pitals in Guangzhou during late 1998. Metod To test 20 antimicrobials of 983 Gram negative isolates and 10 antibiotics of 472 Gram positive cocci with disk diffusion methods. Results The sensitvity sequences of 19 an-trimicrobials to the Enterobacterieae isoates were determined. The average detection rates of ESBLs of the twelve were 40.7～45.7% in Enterobacteriaceae. The most sensitive antibiotic for the other pathogenic bacte-ria were also determined. Conclusion Comparing to the results of the multiceter survillances of both abroad and China, the bacteria resistance baseline is in a high level in our. Imipenem and vancomycin are the best drugs for treatment of Gram negative baciili and positive cocci infections respectively.
出处
《广州医药》
1999年第4期58-63,共6页
Guangzhou Medical Journal
基金
广州市科委科研重点项目!98-Z-01-33
关键词
监测
细菌
耐药性
抗生素
病原菌
Surveillance
resistance
bacteriae
antibiotic
