摘要
目的 :探讨细胞免疫在支气管哮喘发病中的作用。方法 :测定支气管哮喘急性发作期 ( 2 8例 )、缓解期 ( 15例 )患者及正常对照组 ( 15例 )T细胞亚群 (单克隆抗体免疫荧光法 )和血清可溶性白细胞介素 2受体 (sIL 2R)水平。结果 :急性发作组外周血CD+ 8明显高于对照组 (P <0 0 1),而缓解组与正常对照组比较各指标均无显著性差异(P >0 0 5 )。说明T细胞免疫功能失衡及T细胞活化在支气管哮喘发病中起着重要作用 ,血清sIL 2R的检测对于监测支气管哮喘病情变化有一定价值。
Objective:Investigate the mechanism of T lymphocyte activation in bronchial asthma.Method:The peripheral T lymphocytes were measured via indirect monoclonal antibody immunofluorescence technique and soluble interleukin 2 receptors were measured via ELISA sandwinch technique in 28 cases of acute asthmatic attack,15 cases of remission and 15 cases of control group.Result:CD 8 levels in acute attack patients were higher than those in health subjects,the levels of sIL 2R in these patients were higher than those in health and remission patients,but there are no difference in CD 4 or CD 4/CD 8 and sIL 2R levels between health group and remission.Concluson:Cellular immunity disorer and T cell activation play important role in asthmatic pathogenesis,to measure the Serum SIL 2R level of patients be useful for monitoring asthmatic status change.
出处
《河北医药》
CAS
1999年第4期228-229,共2页
Hebei Medical Journal
关键词
哮喘
T细胞亚群
SIL-2R
Asthma T lymphocyte subtypes Soluble interleukin 2 receptors(sIL 2R)
