期刊文献+

奥沙利铂联合卡培他滨治疗晚期胃癌的临床观察

暂未订购
导出
摘要 目的观察奥沙利铂联合卡培他滨治疗晚期胃癌的疗效和毒性反应。方法选择我院2007年2月至2010年2月收治的36例晚期胃癌患者,采用XELOX方案:奥沙利铂130mg/m2第1天静脉滴注,卡培他滨2500mg/(m2·d),分2次第1~14天口服,每3周为1个治疗周期,2周期后评价疗效和毒副作用。结果 36例患者均化疗2周期以上,其中完全缓解1例,部分缓解18例,稳定7例,进展10例,有效率52.8%。主要不良反应为白细胞减少15例,末梢神经炎11例,手足综合征10例,贫血8例,恶心、呕吐7例,腹泻6例,脱发3例,不良反应均为I~Ⅲ级,其中I级占59.2%,Ⅱ级占37.6%。结论奥沙利铂联合卡培他滨治疗晚期胃癌的疗效确切,不良反应较轻,患者可以耐受。
出处 《中国实用医药》 2010年第32期101-102,共2页 China Practical Medicine
  • 相关文献

参考文献9

  • 1Parkin DM,Bray F,Ferlay J,et al.Gloabl cancer statistics,2002.CA Cancer J Clin,2005,55:74-108.
  • 2Pyrhonen S,Kuitunen T,Nyandoto P,et al.Randomised comparison of fluorouracil,epidoxorubicin and methotrexate(FEMTX)plus supportive care with supportive care alone inpatients with non-resectable gastric cancer.Br J Cancer,1995,71(3):587-591.
  • 3Glimelius B,Ekstrom K,Hoffman K,et al.Randomized comparison between chemotherapy plus best supportive care with best supportive in advanced gastric cancer.Ann Oncol,1997,8(2):163-168.
  • 4W.Koizumi.Chemotherapy for adyanced gastric cancer:review of global and japaneese status.Gastrointestinal Cancer Research,2007,1(5):197-203.
  • 5孙燕.内科肿瘤学.人民卫生出版社,2003:994-995.
  • 6Ohtsu A.Chemotherapy for metastatic gastric cancer:past,present,and future.J Gastroenterol,2008,43(4):256-264.
  • 7Okines A,Chau I,Cunningham D.Capecitabine in dvanced gastric Cancer.Expert Opin Pharmacother,2007,8(16):2851-2861.
  • 8Takiuchi H,Goto M,Kawabe S,et al.Second-line chemotherapy in gasric cancer.Gan To Kagaku Ryoho,2005,32(1):19-23.
  • 9Sumpter K,Harper-Wynne C,Cunningham D,et al.Report of two protocol planned interim analyses in a randomized multicentre phase Ⅲ study comparing capecitabine with fluorouracil and oxaliplatin with cisparing in patients with advanced oesophagogastric cancer receiving ECF.Br J Cancer,2005,92(11):1976-1983.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部