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Synthesis and in vitro anti-hepatitis B virus activity of 1H-benzimidazol-5-ol derivatives 被引量：1

Synthesis and in vitro anti-hepatitis B virus activity of 1H-benzimidazol-5-ol derivatives
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摘要 A series of 1H-benzimidazol-5-ol derivatives were synthesized and evaluated for their anti-hepatitis B virus(HBV) activity and cytotoxicity in HepG2.2.15 cells.Half of the tested compounds were found to be potent against HBsAg secretion with IC50 values less than 100μmol/L.Compounds 14c,14d,and 14e showed significant inhibitory activity to the viral antigen HBeAg. A series of 1H-benzimidazol-5-ol derivatives were synthesized and evaluated for their anti-hepatitis B virus(HBV) activity and cytotoxicity in HepG2.2.15 cells.Half of the tested compounds were found to be potent against HBsAg secretion with IC50 values less than 100μmol/L.Compounds 14c,14d,and 14e showed significant inhibitory activity to the viral antigen HBeAg.
作者 Dong Chen Xin Zhai Qiu Hui Yuan Jian Luo Si Chang Xie Ping Gong
机构地区 Key Laboratory of Original New Drugs Design and Discovery of Ministry of Education
出处 《Chinese Chemical Letters》 SCIE CAS CSCD 2010年第11期1326-1329,共4页 中国化学快报(英文版)
关键词 1H-benzimidazol-5-ol SYNTHESIS Anti-HBV activity 1H-benzimidazol-5-ol Synthesis Anti-HBV activity
分类号 O626 [理学—有机化学]
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参考文献10

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引证文献1

Chinese Chemical Letters
2010年 第11期

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