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镍化合物细胞损伤中自由基、ATP及Ca^(2+)变化的研究进展

Review on Research of the Change of Free Radicals,ATP and Ca^(2+) in Cell Damaged by Nickel Compounds
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摘要 镍化合物(nickel compounds)是人类在生产和生活中广泛接触的工业物质。镍化合物对细胞的损伤表现主要是以细胞自由基、磷酸三腺苷(ATP)和钙离子(Ca2+)及相关酶类和相关基因的变化。为进一步了解镍化合物对细胞自由基、ATP和Ca2+变化的影响,本文综述报道国内外对镍化合物细胞损伤中自由基、ATP和Ca2+方面变化的研究进展。 Nickle compounds are industrial materials with widely contact to human living and production.Nickle compounds mainly injury the cell in free radical,ATP and Ca2＋ and genes associated with related enzyme changes.For research cell damaged by the nickel compounds,a review on free radical,ATP and Ca2＋ in cell damaged by nickel compounds is presented.
作者 闫铭锋 程宁
机构地区 兰州大学基础医学院免疫系 兰州大学甘肃省新药临床前研究重点实验室
出处 《环境与职业医学》 CAS 北大核心 2010年第11期704-706,共3页 Journal of Environmental and Occupational Medicine
关键词 镍化合物 活性氧自由基 活性氮自由基 脂质过氧化 磷酸三腺苷 钙离子 nickel compounds reactive oxygen species reactive nitrogen species lipid peroxidation adenosine-triphosphate（ATP） Ca2＋
分类号 R114 [医药卫生—卫生毒理学]
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参考文献25

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环境与职业医学
2010年 第11期

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