摘要
目的:研究他克莫司在低谷浓度肝移植患者的药动学,并在每天总药量不增加的前提下,调整给药方案,使患者的谷浓度达到有效浓度范围。方法:对6例低谷浓度的肝移植患者进行药动学研究,将每12小时给药1次改为每8小时给药。采用微粒子酶免疫分析法(MEIA)测定血药浓度,比较给药方案调整前、后他克莫司谷浓度。结果:调整后的他克莫司平均谷浓度高于调整前的谷浓度(P<0.05),他克莫司的平均谷浓度由调整前的5.8μg.L-1升至调整后的7.8μg.L-1,升高了23.3%。结论:对于他克莫司低谷浓度的肝移植患者,在不增加日给药剂量的前提下,可以通过缩短给药间隔增加谷浓度,使血药浓度更加平稳。
OBJECTIVE： To study the pharmacokinetics of lower trough concentration of tacrolimus in patients underwent liver transplantation, and to adjust dosage regimen on the basis of unaltered daily dose of drugs in order to reach effective trough concentration range of tacrolimus. METHODS： 6 patients with trough concentration of tacrolimus beyond effective range were included in patients with low trough concentration. The pharmacokinetics of tacrolimus was studied. Patients were given medicine every 8 hours instead of every 12 hours. The blood concentration was determined by microparticle enzyme immunoassay （MEIA）. The trough con- centration of tacrolimus after adjustment was compared with before adjustment. RESULTS： In dosage regimen of giving medicine every 8 hours, the trough concentration of tacrolimus was higher than before adjustment （P〈0.05）. Mean trough concentration of FK506 increased to 7.8 μg·L-1 from before adjustment of 5.8 μg·L-1. Mean trough concentration of FK506 increased by 23.3%. CONCLUSIONS： It＇s a rapid effective and safe measure to raise trough concentration by shortening the dosing interval under the same daily total administration dose.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第46期4357-4358,共2页
China Pharmacy
关键词
他克莫司
肝移植
谷浓度
药动学
给药方案
Tacrolimus （FK506）
Liver transplantation
Trough concentration
Pharmacokinetics
Dosage regimen
