摘要
目的了解海藻酸钾对原发性高血压(EH)人群的影响。方法将102例EH患者随机分为海藻酸钾组和对照组。原服用降压药物不变,海藻酸钾组每天服用含海藻酸钾的奶粉50g(含海藻酸钾3.5g),对照组服用普通奶粉,连续50d。对每位受试者进行血压、血常规、肝功能、肾功能、血糖、血脂测定,同时对临床症状、不良反应等进行问卷调查。结果海藻酸钾组血压随服用时间逐步下降,自第21d开始显著降低(P<0.05),服用海藻酸钾50d后,海藻酸钾组收缩压、舒张压平均下降13.89、10.15mmHg,降压有效率为60.78%。主要临床症状积分显著降低(P<0.05),头痛、眩晕、心悸、耳鸣、失眠、腰膝酸软6项临床症状改善有效率及改善总有效率与对照组比较差异显著(P<0.05),改善总有效率达76.47%。结论海藻酸钾可有效辅助降压药物降低EH人群血压值,缓解临床症状。
Objective To study the effect of potassium alginate on the clinical manifestations of essential hypertension （EH） patients. Method One hundred and two EH patients were randomly divided into potassium alginate treated group and control group. Antihypertensive drugs were taken as usual. Patients in the treated group were given milk powder mixed with 3. 5 g potassium alginate while the patients in control group were given milk powder only for 50 consecutive days. Blood pressure, blood routine, liver function, renal function, blood sugar and blood lipids of each subject were determined. The clinical symptoms and adverse reactions were investigated with questionnaires. Results The blood pressure of the potassium alginate treated group were decreased step by step following the intake of potassium alginate,and the blood pressure decreased significantly from the 21st day （P 0. 05） of the trial. After taking potassium alginate for 50 days,the decrease of systolic and diastolic pressure in the treated group was at an average of 13. 89 mmHg and 10. 15 mmHg respectively,and the effective power of lowing blood pressure was 60. 78% . The scores of main clinical symptoms were significantly improved in the potassium alginate treated group,such as headache,dizziness,palpitations,tinnitus, insomnia,malaise of knee and waist,and the total efficiency was significantly different between the treated and control group. The total efficiency of improvement was 76. 47% . Conclusion Potassium alginate is effective in assisting antihypertensive drugs for decreasing blood pressure and alleviating clinical manifestations of essential hypertension patients.
出处
《中国食品卫生杂志》
北大核心
2010年第6期511-515,共5页
Chinese Journal of Food Hygiene
关键词
海藻酸钾
原发性高血压
降血压
Potassium Alginate
Essential Hypertension
Decreasing Blood Pressure
