摘要
目的 探讨血清高敏C-反应蛋白（hs-CRP）、S100β蛋白及神经元特异性烯醇化酶（NSE）与急性脑梗死病情和预后的关系.方法 急性脑梗死患者170例,其中轻度、中度及重度脑梗死分别为41例、83例和46例 腔隙性及小面积、大面积脑梗死分别为43例、79例和48例.80例门诊体检者为正常对照组.用免疫透射比浊法测定hs-CRP水平,用双抗体夹心ELISA法测定S100β蛋白及NSE水平.结果 急性脑梗死患者血清hs-CRP、S100β蛋白及NSE水平明显高于对照组,且病情愈重和梗死面织愈大,血清 hs-CRP、S100β蛋白及NSE水平愈高（P〈0.05） 治疗无效组血清hs-CRP、S100β蛋白及NSE水平明显高于治疗有效组（P〈0.01） hs-CRP、S100β及NSE水平呈正相关.结论 血清hs-CRP、S100β蛋白、NSE可能是判断急性脑梗死患者病情和预后的指标.
Objective To discuss the relationship between high - sensitivity C - reactive protein （hs-CRP）, S100β, neuron specific enolase （NSE） level and the conditions, prognosis of acute cerebral - infarction. Methods A total of 170 acute cerebral - infarction patients, among them there were 41 mild, 83 moderate and 46 severe cerebral - infarction patients respectively. Lacunar and small, large areas of cerebral infarction were 43cases, 79 cases and 48eases. 80 cases of out- patient physical examination were normal controls. The content of hs - CRP was determined by immune transmission nephelometry method and the content of S100β, NSE level by ELISA. Results The contents of hs - CRP, S100β, NSE level were higher obviously in acute cerebral - infarction patients than in the contrast group （P〈0.05）. The contents of hs -CRP, S100β protein and NSE were higher in the ineffective treatment patients than in the effective group （P 〈 0. 01 ）. hs - CRP, S100β and NSE level were positively correlated. Conclusion hs - CRP, S100β protein and NSE level are good indexes to judge the disease conditions and prognosis of acute cerebral - infarction patients.
出处
《中国急救医学》
CAS
CSCD
北大核心
2010年第11期990-993,共4页
Chinese Journal of Critical Care Medicine
