摘要
目的观察吡格列酮联合二甲双胍治疗2型糖尿病的临床疗效。方法152例2型糖尿病患者按数字表法随机分为对照组和治疗组各76例，对照组口服二甲双胍0．5g，3次／d；治疗组给予吡格列酮30mg，1次／d，同时口服二甲双胍0．5g，3次／d。两组连续治疗3个月。结果治疗组治疗总有效率96．1％明显高于对照组的84．2％（P〈0．05）；两组治疗后空腹血糖和餐后血糖均明显低于治疗前（均P〈0．05），治疗组较对照组降低更明显（均P〈0．05）；两组均未发生严重不良反应。结论吡格列酮联合二甲双胍治疗2型糖尿病临床效果显著，优于单用二甲双胍治疗。
Objective To observe the effects of pioglitazone combined with mefformin in type 2 diabetes. Methods 152 type 2 diabetes patients were randomly divided into control group and treatment group. The control group was treated with mefformln 0. 5g,3 time every day. The treatment group received pioglitazone 30mg, one time every day, except took mefformin O. 5 g,3 time every day. Two groups all completed a therapeutic period of 3 months. Results The effect of the treatment group compared with the control group has significantly statistical difference （ P 〈 O. 05）. Fasting blood glucose and postprandial blood glucose ： compared back and forth, the treatment group and control group all have significantly statistical difference（ all P 〈 0.05 ） ;the result of the treatment group compared with that of the control group has significant difference also（ all P 〈 0. 05 ）. Conclusion The therapeutic effect of pioglitazone combined with mefformin on type 2 diabetes patients was much better than mefformin only.
出处
《中国基层医药》
CAS
2010年第21期2932-2933,共2页
Chinese Journal of Primary Medicine and Pharmacy
