摘要
目的:探讨负性生活事件、人格特征与口腔扁平苔藓患者血清皮质醇的相关性。方法:采用生活事件量表、艾森克人格问卷评定口腔扁平苔藓患者68例与对照组43例,并采集静脉血进行血清皮质醇测定。结果:生活事件量表结果显示OLP患者生活事件总分(113.65±39.32),负性生活事件分(67.62±28.83)高于对照组;艾森克人格问卷结果显示OLP患者外倾性(33.04±10.25)得分低于对照组,神经质(53.83±8.33)和精神质(55.04±12.39)得分高于对照组。OLP组血清皮质醇浓度(434.15±123.43)nmol/L明显高于对照组(382.14±83.63)nmol/L,差别有统计学意义(P<0.01)。OLP组血清皮质醇与负性生活事件(r=0.307)和神经质(r=0.293)呈正相关。结论:负性生活事件、消极的人格特征通过应激反应导致OLP患者皮质醇升高,皮质醇的异常说明患者机体心理内分泌免疫网络的紊乱。
Objective：The aim of the study is to explore the relationship between negative life events,personality traits and serum cortisol in patients with oral lichen planus（OLP）.Methods：68 patients with OLP and 43 control（with dental caries）were enrroled and evaluated with Life Event Scale（LES）and Eysenck Personality Questionnaire（EPQ）.Results：The total scores of life events（113.65±39.32）and negtive life events（67.62±28.83）in patients with OLP were significant higher than those in the control group（87.25±28.62 and 25.18±9.66）（P〈0.01）.The scores of extroversion-introversion（33.04±10.25）in patients with OLP were significant lower than those in the control group（45.32±11.42,P〈0.05）,the scores of psychotics（53.83±8.33）and neuroticism（55.04±12.39）were significant higher than those in the control group（46.10±9.53 and 47.62±7.13）（P〈0.05）.Significantly higher concentration of serum cortisol was observed in patients with OLP（434.15±123.43 nmol/L）than in the controls（382.14±83.63 nmol/L）,the concentration of serum cortisol in patients with OLP was positively correlated with negative life event（r=0.307）and neuroticism（r=0.293）.Conclusion：Negative life events,personality traits may result in higher concentration of serum cortisol in patient with OLP,the abnormality of cortisol level may show the disorder of psychology-endocrine-immune net in OLP patients.
出处
《实用口腔医学杂志》
CAS
CSCD
北大核心
2010年第6期796-798,共3页
Journal of Practical Stomatology
