摘要
目的:探讨芦荟对大鼠幽门结扎型胃溃疡的影响及机制.方法:42只Wistar大鼠随机分为3组,即正常对照组、溃疡模型组和芦荟处理组.采用结扎大鼠幽门的方法建立大鼠胃溃疡模型,检测各组大鼠胃溃疡指数(UI)、胃液酸度、胃蛋白酶活性、胃黏膜超氧化物歧化酶(SOD)活性及丙二醛(MDA)含量.结果:与正常对照组比较,溃疡模型组大鼠UI增大,胃液酸度、胃蛋白酶活性和MDA含量升高(39.2分±2.5分vs0.0分;67.25mmol/L±7.1mmol/L vs 41.31mmol/L±6.3mmol/L,t=7.2256;171.25U/mL±29.25U/mL vs 98.34U/mL±21.13U/mL,t=5.3453;0.57NU/mg pro±0.12NU/mg pro vs 0.31NU/mg pro±0.11NU/mg pro,t=4.2207;均P<0.01),SOD活性降低(126.14NU/mg pro±13.3NU/mg pro vs 189.23NU/mg pro±15.3NU/mg pro,t=8.2339,P<0.01).与溃疡模型组比较,芦荟处理组大鼠UI、胃液酸度、胃蛋白酶活性及MDA含量降低(t=11.7584,P<0.01;t=6.4310,P<0.01;t=3.0276,P<0.05;t=5.1428,P<0.01),SOD活性升高(t=5.3003,P<0.01).结论:芦荟具有抗大鼠幽门结扎型胃溃疡的作用,其作用机制可能与抑制体内的过氧化反应、胃酸分泌和胃蛋白酶活性有关.
AIM：To investigate the effects of aloe on gastric ulcer in pylorus-ligated rats and to explore potential mechanisms involved.METHODS：Forty-two Wistar rats were randomly divided into three groups：normal control group,ulcer model group and aloe treatment group.Gastric ulcer was induced in rats by ligating the pylorus.The gastric ulcer index （UI）,acidity and pepsin activity of gastric juice,and superoxidatase （SOD） activity and malondialdehyde （MDA） level in gastric mucosa were measured in rats of each group.RESULTS：Compared with the normal control group,the UI,acidity and pepsin activity of gastric juice,and MDA level were increased （39.2±2.5 vs 0.0;67.25 mmol/L±7.1 mmol/L vs 41.31 mmol/L±6.3 mmol/L,t=7.2256;171.25 U/mL±29.25 U/mL vs 98.34 U/mL±21.13 U/mL,t=5.3453;0.57 NU/mg pro±0.12 NU/mg pro vs 0.31 NU/mg pro±0.11 NU/mg pro,t=4.2207;all P0.01） and SOD activity was decreased （t=8.2339,P0.01） in the ulcer model group.Compared with the ulcer model group,the UI,acidity and pepsin activity of gastric juice,MDA level were decreased （t=11.7584,6.4310,3.0276 and 5.1428,respectively;all P0.01） and SOD activity was increased （t=5.3003,P0.01） in the aloe treatment group.CONCLUSION：Aloe improves gastric ulcer in pylorus-ligated rats possibly by inhibiting lipid peroxidation,gastric acid secretion and pepsin activity.
出处
《世界华人消化杂志》
CAS
北大核心
2010年第28期3008-3011,共4页
World Chinese Journal of Digestology
