摘要
目的 探讨血清胱抑素C（SCys C）浓度检测能否作为肾移植受者随访中移植肾功能测定的理想指标.方法 选择肾移植术后接受长期随访的受者70例,于随访当日检测受者SCys C和血清肌酐（SCr）水平,同时用99mTc-DTPA肾动态显像测定肾小球滤过率（GFR）,比较SCys C和SCr与GFR的相关性,并应用受试者工作特征曲线（ROC曲线）评价两者在诊断移植肾功能轻度损伤（GFR＜1 ml/s）中的效果.结果 随访的肾移植受者中,SCys C和SCr与GFR均呈负相关,相关系数分别为-0.82和-0.66（P＜0.01）.SCys C用于诊断移植肾功能轻度损伤的敏感度、特异度和阳性预测值（PPV）均高于SCr.SCys C的ROC曲线下面积高于SCr（分别为0.935和0.877）,但两者比较,差异无统计学意义（P＞0.05）.结论 在肾移植术后的随访中,受者SCys C与GFR的相关性比SCr更高,可作为评估移植肾功能的较理想指标.
Objective To evaluate whether serum cystatin C （SCys C） could be used as an ideal index to assess renal function of renal transplant recipients during posttransplant follow-up.Methods Seventy patients who were followed up for at least 6 months after renal transplantation in our centre were recruited in the study. SCys C and serum creatinine （SCr） were determined during the follow-up period, and glomerular filtration rate （GFR） was measured using an isotope Tc99m DTPA.The correlation between SCys C, SCr and GFR was analyzed. The performance of SCys C and SCr in diagnosing the mild impairment of renal allgraft function （GFR 〈 1 ml/s） was evaluated using ROC curve. Results Both SCys C and SCr had a linear negative correlation with GFR （r = -0. 82 and -0. 66 respectively, P〈0. 01 ）. The sensitivity, specificity and positive predictive values （PPV） of SCys C for diagnosing the mild impairment of renal allgraft function were higher than those of SCr,but the AUC of SCys C did not differ from that of SCr significantly （0. 935 vs. 0. 877, P〉0. 05）.Conclusion SCys C could be used an ideal index to evaluate the allograft renal function for its better correlation with actual GFR.
出处
《中华器官移植杂志》
CAS
CSCD
北大核心
2010年第11期648-650,共3页
Chinese Journal of Organ Transplantation
关键词
胱抑素C
肾移植
血清肌酐
肾小球滤过率
Cystatin C
Kidney transplantation
Serum creatinine
Glomerular filtration rate
