摘要
目的探讨IL-5、IL-15和IL-18在变应性鼻炎、支气管哮喘、变应性鼻炎合并哮喘疾病中的作用。方法采用双抗体夹心ELISA测定法对33例支气管哮喘患者、35例变应性鼻炎患者、35例变应性鼻炎合并哮喘的患者及35例正常健康查体者血清中IL-5、IL-15和IL-18的水平进行检测。结果支气管哮喘、变应性鼻炎、变应性鼻炎合并哮喘的患者血清中IL-5、IL-15和IL-18水平较正常对照组升高（P〈0．01），IL-5、IL-15，IL-18水平在变应性鼻炎合并哮喘组均高于鼻炎组与和哮喘组；鼻炎组IL-5水平高于哮喘组（P=0．003），哮喘组IL-18水平高于鼻炎组（P=0．001）。结论IL-5、IL-15和IL-18参与了过敏性鼻炎和哮喘的发病过程；变应性鼻炎合并哮喘的炎症程度较高；哮喘和鼻炎因发病部位不同炎症反应也有不同。
Objective To explore the effect of IL-5,IL-15 and IL-18 in pathogenesis of patient with allergic rhinitis （AR） and bronchial asthma. Methods The serum samples were obtained from 33 patients with asthma,35 patients with AR, 35 patients with AR and BA, and 35 controls. The serum levels of IL-5,IL-15 and IL-18 were measured by ELISA. Results The levels of IL-5, IL-15 and IL-18 were greatly increased in all patient groups than the control group （P 〈 0.01 ）. The levels of IL-5, IL-15 and IL-18 were greatly increased in AR and BA group than the group of BA and the group of AR. The level of IL-5 in the group of AR was higher than that in the group of BA. （P =0. 003）. The level of IL-18 in the group of BA was higher than that in the group of AR （ P = 0.001 ）. Conclusions IL-5 , IL-15 and IL-18play a prominent role in the pathogenesis of AR and BA. Inflammations in the group of AR accompanying BA group are much higher, there is difference in in- flammations between BA and AR.
出处
《国际免疫学杂志》
CAS
北大核心
2010年第6期495-497,共3页
International Journal of Immunology
