摘要
目的探讨乳腺恶性腺肌上皮瘤(MAME)的临床病理特征。方法对1例罕见的乳腺恶性腺肌上皮瘤进行组织学观察和免疫组化分析,并复习文献。结果镜下见肿瘤由增生的腺上皮和肌上皮两种成分构成,前者构成管状结构的内层,后者构成管状结构的外层以及实性区域。腺上皮可见鳞状上皮化生现象,局灶腺上皮呈高度非典型增生,局灶肌上皮过度生长并可见轻度非典型性,肿瘤边缘呈浸润性生长。结论乳腺恶性腺肌上皮瘤的上皮、肌上皮成分均可发生恶变,同时恶变者罕见。以组织学结合免疫组化检测是确诊本病的关键。
Objective To analyze the clinical characteristics of malignant adenomyoepithelioma of the breast. Methods Histologic and immunohistoehemical features were reviewed in a case of malignant myoepithelioma. Results The tumor had distinct components of epithelial and myoepithelial cells, the fomer lined the lumina of the tubular structures, while the latter constituted the outer layer of the tubular structures and the solid areas. Squamous metaplasia of glandular epithelium was commomly noted. Foei of epithelial cells showed severe dysplasia. Foci of myoepitbelial cells proliferated with light dysplasia. The tumor had invasive border. Conclusion The epithelial or myoepithelial components of breast adenomyoepitheliaoma can be transformed into malignancies. Malignant adenomyoepithialioma with both components is rare. Histology combined with immunohistochemistry can assist in the diacnosis of this disease.
出处
《诊断病理学杂志》
CSCD
2010年第5期349-352,共4页
Chinese Journal of Diagnostic Pathology
关键词
乳腺
恶性腺肌上皮瘤
免疫组化
Breast
Malignant adenomyoepithelioma
hnmunohistochemistry
