摘要
目的了解北京市高收入女性人群宫颈高危HPV感染常见分型及高危HPV感染与液基细胞学异常的相关性。方法对2008年1月至2008年12月间就诊于北京五洲女子医院妇科门诊的女性2023例,采用导流杂交法进行16、18、31、33、35、39、45、51、52、53、56、58、59、66、68、6、11、42、43、44、CP8304等21种宫颈人乳头状瘤病毒亚型的分型检测。同时进行液基薄层细胞学检测(TCT)。结果检测2023人次中感染高危HPV亚型618例,感染率30.5%,排在前5位的高危亚型是58(21.68%)、16(16.99%)、33(11.32%)、53(8.09%)、52(7.76%)。感染高危HPV618例中TCT异常的278例,其中ASCUS133例、LSIL124例、HSIL21例。结论北京市高收入女性人群宫颈高危HPV感染率较高,主要为单一感染,感染亚型主要是58、16、33、53、52型。其中16、58型的致病性较其他分型高。
Objective To explore the HPV type in Beijing high-income women with cervical HPV infection and the correlation of high-risk HPV infection and abnormal liquid-based cytology.Methods 2 023 patients who visited Beijing Wuzhou Women＇s Hospital from January to December in 2008 were recruited in this study.The subtypes of HPV including 16,18,31,33,35,39,45,51,52,53,56,58,59,66,68,6,11,42,43,44 and CP8304 were detected using HybriMiax method,at the same time liquid-based thin layer cytology（TCT）were tested.Results There were 618 patients with high-risk HPV subtype positive in the 2023 patients with the infection rate of 30.5%,the top five high-risk subtypes were 58（21.68%）,16（16.99%）,33（11.32%）,53（8.09%）and 52（7.76%）.We detected 278 patients with abnormal TCT results among the patients with high-risk HPV infection：133 were ASCUS,124 were LSIL and 21 were HSIL.Conclusions The high-risk cervical HPV infection rate in Beijing High-income women was high,most were single HPV infection.The frequent subtype were 58,16,33,53 and 52 type,of which 16 and 58 type have higher pathogenicity than others.
出处
《中国妇产科临床杂志》
2010年第6期417-419,共3页
Chinese Journal of Clinical Obstetrics and Gynecology
