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假基因研究进展 被引量：4

Advances in Research on Pseudogenes
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摘要 假基因是功能基因的缺陷拷贝,它在序列结构上与功能基因非常相似,但已丧失了正常的蛋白质编码功能.假基因曾被认为是一类典型的非编码"垃圾DNA",而如今人们发现假基因在基因表达调控和基因组进化过程中发挥着重要作用.从假基因的起源、序列结构特征、假基因的识别、假基因在染色体上的分布、分子进化规律,以及假基因功能等几个方面较为全面地介绍了该领域的最新研究进展. Pseudogenes, disabled copies of functional genes, are structurally similar to its parantal genes, but lost their ability to produce proteins. Pseudogene was used to be considered as a typical kind of non-coding ＂junk DNA＂ . Increasing investigations, however, have shown that pseudogenes play important roles in gene regulation and genome evolution. The progress of research on pseudogenes is summarized in light of the origin and sequence characteristics of pseudogenes, identification of pseudogenes, genomic distribution, behaviour of its molecular evolution and functioning.
作者 刘国庆 白音宝力高 邢永强
机构地区 内蒙古科技大学数理与生物工程学院 共青团内蒙古师范大学委员会
出处 《生物化学与生物物理进展》 SCIE CAS CSCD 北大核心 2010年第11期1165-1174,共10页 Progress In Biochemistry and Biophysics
基金 内蒙古自治区高等学校科学研究项目(NJ10098) 内蒙古科技大学创新基金资助项目(2009NC005)~~
关键词 假基因 假基因识别 假基因进化 假基因功能 pseudogene, identification ofpseudogenes, evolution ofpseudogenes, pseudogene function
分类号 Q61 [生物学—生物物理学]
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参考文献67

  • 1Wickelgren I. Spinning junk into gold. Science, 2003, 300(5626): 1646-1649.
  • 2Balakirev E S, Ayala F J. Pseudogenes: are they " junk" or functional DNA?. Annu Rev Genet, 2003, 37:123-151.
  • 3Vanin E F. Processed pseudogenes: characteristics and evolution. Annu Rev Genet, 1985, 19:253-272.
  • 4Esnault C, Maestre J, Heidmann T. Human LINE retrotransposons generate processed pseudogenes. Nat Genet, 2000, 24(4): 363-367.
  • 5Kazazian H H. Mobile elements: drivers of genome evolution. Science, 2004, 303(5664): 1626-1632.
  • 6Li W H, Gojobori T, Nei M. Pseudogenes as a paradigm of neutral evolution. Nature, 1981, 292(5820): 237-239.
  • 7Zhang Z, Harrison P M, Liu Y, et al. Millions of years of evolution preserved: a comprehensive catalog of the processed pseudogenes in the human genome. Genorne Res, 2003, 13(12): 2541-2558.
  • 8Torrents D, Suyama M, Zdobnov E, et al. A genome-wide survey of human pseudogenes. Genome Res, 2003, 13(12): 2559-2567.
  • 9Liu Y, Harrison P M, Kunin V, et al. Comprehensive analysis of pseudogenes in prokaryotes: widespread gene decay and failure of putative horizontally transferred genes. Genome Biol, 2004, 5(9): R64.
  • 10Zhang Z, Gerstein M. Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. Genomies, 2003, 81(5): 468-480.

二级参考文献28

  • 1Maestre J, Tchenio T, Dhellin O, Heidmarm T. mRNA retroposition in human cells: processed pseudogene formation. EMBOJ, 1995,14(24):6333-6338
  • 2Balakirev ES, Ayala FJ. Pseudogenes: are they "junk" or functional DNA? Annu Rev Genet, 2003,37:123-151
  • 3Honama K, Fukuchi S, Kawabata T, Ota M, Nishikawa K. A systematic investigation identifies a significant number of probable pseudogenes in the Escheriehia coli genome. Gene, 2002,294(1-2):25-33
  • 4Harrison PM, Echols N, Gerstein M. Digging for dead genes: an analysis of the characteristics of the pseudogene population in the Caenorhabditis elegans genome. Nucleic Acids Res, 2001,29(3):818-830
  • 5Torrents D, Suyama M, Zdobnov E, Bork P. A genome-wide survey of human pseudogenes. Genome Res, 2003,13(12): 2559-2567
  • 6Zhang Z, Harrison PM, Liu Y, Gerstein M. Millions of years of evolution preserved: a comprehensive catalog of the processed pseudogenes in the human genome. Genome Res, 2003,13(12):2541-2558
  • 7Petrov DA, Aminetzach YT, Davis JC, Bensasson D, Hirsh AE. Size matters: Non-LTR retrotransposable elements and ectopic recombination in Drosophila. Mol Biol Evol, 2003,20 (6):880-892
  • 8Bartolome C, Maside X, Charlesworth B. On the abundance and distribution of transposable elements in the genome of Drosophila melanogaster. Mol Biol Evol, 2002,19(6):926-937
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  • 10Duret L, Marais G, Biemont C. Transposons but not retrotransposons are located preferentially in regions of high recombination rate in Caenorhabditis elegans. Genetics, 2000, 156(4): 1661 - 1669

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生物化学与生物物理进展
2010年 第11期

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