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热化疗对口腔颌面癌患者一氧化氮水平影响的研究 被引量：1

Influence of Thermochemotherapy to the Nitric Oxide Level in Oral Cancer
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摘要 目的:观察热化疗对口腔颌面癌患者NO水平的影响。方法:给予口腔颌面癌患者每周2次,5周一疗程的热化疗处理,处理后观察肿瘤的组织形态学变化,并采用硝酸还原酶法检测患者血清NO的浓度。结果:热化疗后,肿瘤生长受到明显抑制。热化疗前后NO含量有显著性差异(P<0.01)。结论:热化疗可以显著升高荷瘤宿主NO水平,高浓度时具有很好的抗肿瘤效应。 Objective ： To observe the influence of thermoehemotherapy to the nitric oxide level of oral cancer. Methods： Patients with oral cancer were treated by thermochemotherapy twice a week. After treatment of 5 weeks, histomorphologies were observed, the levels of NO of tumor were detected through the nitrate reductase method. Results： After treatment, the growth of tumors was inhibited significantly. The levels of NO in oral cancer patients were significantly different before and after thermochemotherapy （P 〈 0. 01 ）. Conclusion： Thermochemotherapy can improve the levels of NO of tumor bearing significantly. High concentration of NO has an excellent anti-tumor effect.
作者 高向东 杨海锋 王升志 赵君 毛祖彝
机构地区 烟台毓璜顶医院口腔科 烟台市口腔医院 四川大学华西口腔医学院
出处 《肿瘤预防与治疗》 2010年第1期23-26,共4页 Journal of Cancer Control And Treatment
基金 山东省自然科学基金(基金编号:Z2005C01) 山东省优秀中青年科学家科研奖励基金(基金编号:2006BS03016)资助
关键词 一氧化氮 一氧化氮合成酶 肿瘤 热化疗 Nitric Oxide NO Synthase Tumor Thermochemotherapy
分类号 R739.8 [医药卫生—肿瘤]
  • 相关文献

参考文献21

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  • 3赵君,高向东,王升志,毛祖彝.热化疗对荷瘤鼠NO水平影响的研究[J].肿瘤预防与治疗,2009,22(2):117-121. 被引量：1
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二级参考文献36

  • 1Wink DA,Vodocotz Y,Laval J,et al.The multifaceted roles of nitric oxide in cancer[J].Carcinogenesis,1998,19(5):711-722.
  • 2Jenkins DC,Charles IG,Thomsen LL,et al.Robs of nitric oxide in tumor growth[J].Proc Natl Acad Sci U S A,1995,92(10):4392-4396.
  • 3Urano M,Ling CC.Thermal enhancement of melphalan and oxaliplatin cytotoxicity in vitro[J].Int J Hyperthermia,2002,18(4):307-315.
  • 4Brozovic A,Simaga S,Osmak M.Induction of heat shock protein 70 in drug-resistant cells by anticancer drags and hyperthermia[J].Neoplasma,2001,48(2):99-103.
  • 5Ohtsubo T,Park H J,LyonsJ C,et al.Effect of acidic environment and p53 on apoptotis induction by hyperthermia[J].Int J Hyperthermia,2000,16(6):481-491.
  • 6Sawaji Y,Sato T,Takeuchi A,et al.Anti-angiogenic action of hyperthermia by suppressing gene expression and production of tumor-derived vascular endothelial growth factor in vivo and in vitro[J].Br J Cancer,2002,86(10):1579-1603.
  • 7Rosbe KW,Petrusz,et al.Immunhistoehemical characterization of NOS activity in squamous cell carcinoma of the head and neck[J].J Otolamgol Head Neck,1995,113(6):541-544.
  • 8Jiang H,Stewart C A,Leu RW.Tumor target-derived factor synergizcs with INF-γ and LPS,IL-2 or TNF-α to promote macrophage synthase and enhanced nitric oxide-mediated tumor cytotoxity[J].Immunobiology,1995,192(2):321-324.
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肿瘤预防与治疗
2010年 第1期

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