摘要
目的:了解P-选择素及其配体sLeA、sLeX在食管癌组织及区域淋巴结中的表达,探讨其与食管癌侵袭转移的关系。方法:应用组织芯片技术结合免疫组化检测食管鳞癌86例及其淋巴结P-选择素和sialy lewis A(sLeA)、sialylewis X(sLe X)的表达情况,并与16例正常食管鳞状上皮对照。结果:P-选择素在食管癌组织、正常食管鳞状上皮表达率分别为59.3%、12.5%(P<0.05),在转移淋巴结、非转移淋巴结中表达率分别为92.9%、31.3%(P<0.05)。sLeA在食管癌组织,正常食管组织中表达率分别为77.9%、6.25%(P<0.05),在转移淋巴结和非转移淋巴结中表达率分别为97.6%、20.3%(P<0.05)。sLe X食管癌组织、正常食管组织中表达率分别为15.1%、6.25%(P>0.05)。P-选择素和配体sLeA过度表达与食管鳞癌病理分级,TNM分期及淋巴结转移成显著相关性;而配体sLeX在食管癌组织中无过度表达。结论:P-选择素和配体sLeA在食管鳞癌组织、转移淋巴结中表达率明显升高,其与食管癌的侵袭转移有一定关系;配体sLeX与食管癌侵袭转移无关。
Objective： To investigate the expression of p-selectin ,sLeA and sLeX in esophageal squamous carcinoma and lymphatic nodes. Methods： The expression of p-selectin and its ligands in various esophageal tissues were studied by tissue array and immunohistochemistry. Results ： （ 1 ） The expression rates of p-selectin in esophageal squamous carcinoma and normal esophageal tissue were 59.3% and 12.5% （P 〈 0.05 ） respectively. The expression rates in metastatic lymphatic node and nonmetastatic lymphatic node were 92.9% and 32.3% （P 〈 0.05 ） respectively. The expression rates of sLeA in esophageal squamous carcinoma and normal esophageal tissue were 77.9% and 6.25% （P 〈 0.05 ） respectively. The expression rates in metastatic lymphatic node and nonmetastatic lymphatic node were 97.6% and 20.3% （P 〈0.05 ） respectively. The expression rates of sLeX in esophageal squamous carcinoma and normal esophageal tissue were 15.1% and 6.25% （P 〉 0.05 ） respectively. （2） The over-expressions of p-selectin and sLeA were significantly correlated with the biological behavior and the clinical pathological characters of esophageal neoplasm, but there were no over-expressions of sLeX in the esophageal neoplasm. Conclusion： The expression rates of p-selectin and sLeA in esophageal squamous cancer and metastatic lymphatic node are increased, which suggests that there are relations of p-selectin and sLeA with the progession and metastasis of esophageal squamous cancer.
出处
《肿瘤预防与治疗》
2010年第1期5-9,共5页
Journal of Cancer Control And Treatment
