摘要
目的：了解难治性肺结核的耐药特征，为结核病防治提供参考依据。方法：改良罗氏培养基绝对浓度法。结果：１３６例慢性排菌肺结核病人分别对两种或以上主要抗结核药物耐药，其综合耐药率为１００％，其中以耐链霉素、利福平及异烟肼为主，乙胺丁醇、卡那霉素次之，对氟嗪酸也有一定程度的耐药性。结论：对慢性排菌病人的治疗应认真参考药敏结果，慎重选择敏感的药物组合治疗方案，不宜机械地制定“统一”的化疗方案，尽可能避免敏感药物的继发性耐药。
Objective: To probe the susceptibility character of refractory tuberculosis into drug, so as to provide the reference for prevention and cure of tuberculosis. Methods: Absolute density method by improved LJ culture. Resluts : The acquired resistance rate of 136 refractory tuberculosis is 100%. They have leastwise ressisted two drug or more among INH, RFP, EMB, SM etc. Conclusion: It is necessary that the drug should be selected according to the sensitivity test reslts for treatment of refractory tuberculosis. It is not fit to constitute automatically a same chemistry therapy scheme for refractory tuberculosis. No other th an effective and reasonable therapy can promote the tuberculosis epidemic situation to drop down quickly.
出处
《河南医学研究》
CAS
1999年第2期154-155,共2页
Henan Medical Research
关键词
肺结核
药物耐受性
多种耐药性
tuberculosis
drug tolerance
multidrug resistance
