摘要
采用熔融法制备组成(摩尔分数)为24.5%Na2O-24.5%CaO-6%P2O5-45%B2O3的硼酸盐微晶玻璃。选取粒径为300～400μm的硼酸盐微晶玻璃颗粒,用烧结法制备硼酸盐微晶玻璃支架。采用质量损失分析、X射线衍射和电子扫描显微镜等手段分析玻璃支架与模拟体液(simulated body fluid,SBF)溶液的反应过程,研究其生物活性和生物降解性,同时将其与烧结法制备的45S5玻璃支架进行比较。结果表明:与45S5玻璃支架相比,硼酸盐微晶玻璃支架具有更好的生物降解性能和生物活性。硼酸盐微晶玻璃中的玻璃相在SBF中降解速率快,支架表面快速形成羟基磷酸钙的沉积。硼酸盐微晶玻璃中β-NaCaPO4晶相的降解速率慢,可以使支架材料保持较持久的强度。这种双重反应特性使支架材料的降解速率与骨组织的生长速率相配,使支架材料在骨组织工程上具有良好的应用前景。
A borate glass-ceramic with a mole fraction composition of 24.5%Na2O-24.5%CaO-6%P2O5-45%B2O3 was melted.The borate glass ceramic-particles with diameters of 300-400 μm were selected for preparation of porous scaffolds by a sintering method.The reaction process of scaffolds in simulated body fluid（SBF） solution was analyzed by mass change analysis,X-ray diffraction,Fourier transform infrared spectroscopy,and scanning electronic microscopy.The bioactivity and biodegradation of the scaffolds were also studied.The results show that the borate glass-ceramic scaffolds have better biodegradation and bioactivity compared to the 45S5 glass scaffolds.The residual glass phase of the borate glass-ceramic has a high degradation velocity and hydroxylapatite is deposited rapidly on the scaffolds＇ surface,while the rhenanite crystal phase degrades at a low velocity,which can guarantee the long-term mechanical strength of the scaffolds.This combined reaction mechanism enables the biodegradation rate of the scaffolds to match the growth rate of tissues,which makes the scaffolds a good potential prospect in the field of tissue engineering.
出处
《硅酸盐学报》
EI
CAS
CSCD
北大核心
2010年第12期2325-2330,共6页
Journal of The Chinese Ceramic Society
基金
国家自然科学青年基金(50902048)
浦江人才计划(06PJ14027)资助项目
关键词
硼酸盐微晶玻璃
多孔支架
生物活性
β-磷酸钠钙
烧结
borate glass-ceramic
porous scaffolds
bioactivity
β-phosphate calcium sodium
sintering
