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艾司西酞普兰与帕罗西汀治疗首发抑郁症的对照研究 被引量：2

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摘要 目的探讨艾司西酞普兰与帕罗西汀对首发抑郁症治疗的临床疗效和安全性。方法将76例首发抑郁症患者随机分为艾司西酞普兰组(治疗组)和帕罗西汀组(对照组),疗程8周。采用汉密尔顿抑郁量表(HAMD)在治疗前及治疗后1、2、4、6、8周评定疗效;用不良反应症状量表(TESS)评定不良反应。结果在治疗的第一周、第二周末,艾司西酞普兰组的HAMD分值均低于帕罗西汀组,两组分值差异有统计学意义(P<0.05),而在第4、6、8周末,两组患者的HAMD分值差异无统计学意义。在治疗8周末时,艾司西酞普兰组有效率92.1%,显效率86.8%,帕罗西汀组分别为92.1%、84.2%。两组差异无统计学意义。在不良反应方面,两组差异无统计学意义。结论艾司西酞普兰和帕罗西汀治疗首发抑郁症疗效相当,不良反应较少,安全性较好。但艾司西酞普兰起效更快,有利于迅速缓解患者症状。
作者 孙宏俊 王孝祥
机构地区 盐城市第四人民医院精神科
出处 《西南军医》 2010年第6期1092-1093,共2页 Journal of Military Surgeon in Southwest China
关键词 艾司西酞普兰 帕罗西汀 首发抑郁症
分类号 R749.79 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献7

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共引文献152

同被引文献17

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二级引证文献24

西南军医
2010年 第6期

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