期刊文献+

Fas在乳腺癌组织中的表达及其临床意义

暂未订购
导出
摘要 目的:探讨乳腺癌组织中Fas受体的表达及其临床意义。方法:利用流式细胞仪分析乳腺癌及正常乳腺组织细胞表面Fas抗原的表达、浸润性T淋巴细胞计数、肿瘤细胞及浸润性T淋巴细胞凋亡率、周围组织细胞凋亡率等病理指标。结果:随着TNM分期的发展,乳腺癌组织中细胞表达Fas受体细胞数、组织细胞凋亡率、浸润性T淋巴细胞计数显著下降,浸润性T淋巴细胞凋亡率上升;乳腺癌组织表达Fas受体细胞数和T细胞计数有显著的直线正相关性,和T细胞凋亡率有显著的直线负相关性。结论:乳腺癌组织中细胞表面Fas受体表达被抑制,并与TNM分期、淋巴结转移关系密切,提示Fas表达可作为判断乳腺癌恶性程度的生物学指标。
出处 《临床医药实践》 2010年第11期844-846,共3页 Proceeding of Clinical Medicine
  • 相关文献

参考文献3

二级参考文献24

  • 1MinLi Geng-TaoLiu.Inhibition of Fas/FasL mRNA expression and TNF-a release in concanavalin A-induced liver injury in mice by bicyclol[J].World Journal of Gastroenterology,2004,10(12):1775-1779. 被引量:23
  • 2Nakashima M, Sonoda K, Watanabe T. Inhibition of cell growth and induction of apoptotic cell death by the human tumor-associated antigen RCAS1 [ J]. Nat Med,1999,5 (8) :938 -942.
  • 3Sonoda K, Miyamoto S,Hirakawa T, et al. Invasive potency related to RCAS1 expression in uterine cervical cancer [ J ]. Gynecol Oncol, 2005,99(1) : 189 - 198.
  • 4Ikeda K, Stato M, Tsutsumi O,et al. Promoter analysis and chromosomal mapping of human EBA G9 gene [ J ]. Biochem Biophs Res Cammun ,2000,273 (2) :654 - 660.
  • 5Rousseau J,Tetu B, Caron D, et al. RCAS1 is associated with ductal brest cancer progression [J].Bioehem Biophys Res Commun,2002, 293(5) :1544 - 1549.
  • 6Akashi T, Oimomi H, Nishiyama K,et al. Expression and diagnostic evaluation of the human tumor-associated antigen RCAS1 in pancreatic cancer[J]. Pancreas,2003,26(1):49 -55.
  • 7zumi M, Nakanishi Y, Yoshino I,et al. Expression of tumor-associated antigen RCAS1 correlates significantly with poor prognosis in non-small cell lung carcinoma[J]. Cancer,2001,92(2) :446 -451.
  • 8Ikeguchi M,Ohoro S,Maeda Y, et al. Protein and gene expression of tumor-associated antigen RCAS1 in esophageal squamous cell carcinoma[J]. Oncol Rep,2003,10(6):1891 -1894.
  • 9邵润轩,王江滨,王宵伟.凋亡相关因子Fas/FasL在慢性肝炎、原发性肝癌表达的规律[J].世界华人消化杂志,2000,8(8):937-939. 被引量:10
  • 10郭长存,丁杰,喻召才,韩全利,孟繁平,刘娜,樊代明.胃癌MG_7-Ag模拟表位口服DNA疫苗的研制[J].中华肿瘤杂志,2002,24(2):110-113. 被引量:8

共引文献6

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部