摘要
目的 探讨降钙素基因相关肽（ＣＧＲＰ） 在新生儿缺氧缺血性脑病（ＨＩＥ） 中的变化及意义。 方法 采用放射免疫法检测３６ 例ＨＩＥ 患儿和１８ 例正常新生儿血浆ＣＧＲＰ水平变化。 结果 ＨＩＥ急性期血浆ＣＧＲＰ水平明显增高，其中重度组明显高于对照组、轻度组及中度组，中度组高于对照组和轻度组，轻度组与对照组无显著性差异。恢复期血浆ＣＧＲＰ降至正常水平。
Objective To study the changes of plasma calcitonin gene related peptide (CGRP) levels and their clinical implication in newborn infants with hypoxic ischemic encephalopathy (HIE). Methods Dynamic variations of plasma CGRP levels were measured in 36 newborn infants with HIE and 18 normal infants by radioimmunoassay. Results Plasma CGRP levels markedly elevated in acute stage of HIE, especially in severe and moderate groups. There was a gradual decrease in plasma CGRP levels in its convalescent stage. Conclusion CGRP might play a critical role in pathophysiological mechanisms of HIE.
出处
《中华围产医学杂志》
CAS
1999年第2期104-105,共2页
Chinese Journal of Perinatal Medicine
关键词
新生儿
降钙素
基因肽
缺氧缺血性脑病
病理
Infant, newborn Cerebral ischemia Cerebral anoxia Calcitoningene related peptide
