摘要
背景:目前临床上针对颅脑损伤,尤其是运动性颅脑损伤的治疗方法是当前研究的热点问题之一。干细胞具有自我更新能力强、多向分化潜能等特点对运动性颅脑损伤的治疗提供了广阔的应用前景。目的:通过分析运动性颅脑损伤的病理学变化及干细胞技术的应用,探讨干细胞技术应用于运动性颅脑损伤,促进其功能恢复的重要作用。方法:应用计算机检索Medline数据库(1994-01/2010-03)、重庆维普数据库(1994-01/2010-06)、清华同方数据库(1994-01/2010-06)等以"Stemcell,spots brain injury,neural stem cells,mesenchymal stem cells"为英文检索词,以"干细胞;运动性颅脑损伤;神经干细胞;骨髓间充质干细胞"为中文检索词。以与运动性颅脑损伤和干细胞技术相关的文献为纳入标准,以重复性研究、陈旧性文献为排除标准。共检索到126篇相关文献,通过对重复性研究和陈旧性研究之后得到23篇符合标准的文献。结果与结论:干细胞移植技术应用于颅脑损伤的研究虽已取得了很大的进步,但在治疗运动性颅脑损伤的领域尚处于探索阶段,有待进一步研究解决的问题很多,通过分析发现干细胞尤其是神经干细胞和骨髓间充质干细胞对于运动性颅脑损伤的治疗具有十分重要的作用,且其研究前景较为广阔。
BACKGROUND：The present study for the head injury,particularly brain injury in sports is one of the hot topics of current research.Stem cells have self-renewal capacity,differentiation potential,and provide broad application prospects for many sports brain injury.OBJECTIVE：By analyzing the movement of the pathological changes of brain injury and stem cell technology,to study application of stem cell technology to brain injury in sports,and to promote their important role in functional recovery.METHODS：Medline database（1994-01/2010-03）,Chongqing VIP database（1994-01/2010-06）,Tsinghua Tongfang database（1994-01/2010-06） were searched by computer.English key words were ＂stem cell,spots brain injury,neural stem cells,mesenchymal stem cells＂.Chinese key words were ＂stem cell,spots brain injury,neural stem cells,bone marrow mesenchymal stem cells＂.Inclusion criteria：brain injury with exercise and stem cell technology-related literature.Exclusion criteria：repetitive research,old literature.A total of 126 relevant documents were retrieved.Through the study of the repeatability study and the old standard,23 literatures were included.RESULTS AND CONCLUSION：The study of application of stem cell transplantation to brain injury has obtained great progresses.However,its application to brain injury in sports remains in the exploration stage and requires further investigations.We found that stem cells,especially neural stem cells and bone marrow mesenchymal stem cells for the treatment of brain injury in sports play an important role,and its prospects for more extensive research.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2010年第40期7560-7563,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
