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For cancers there is more to life than a longer G-strand

For cancers there is more to life than a longer G-strand
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摘要 Three recent studies from the Wright [1], Chai [2] and de Lange [3] labs have elucidated previously neglected aspects of cancer cell telomere maintenance. Because inhibiting telomere maintenance can selectively kill cancer cells without harming normal cells [4, 5], this new understanding of the mechanism and dynamics involved may provide useful new strategies for treating cancer. Until recently, Three recent studies from the Wright [1], Chai [2] and de Lange [3] labs have elucidated previously neglected aspects of cancer cell telomere maintenance. Because inhibiting telomere maintenance can selectively kill cancer cells without harming normal cells [4, 5], this new understanding of the mechanism and dynamics involved may provide useful new strategies for treating cancer. Until recently,
出处 《Asian Journal of Andrology》 SCIE CAS CSCD 2010年第6期779-782,共4页 亚洲男性学杂志(英文版)
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参考文献17

  • 1Zhao Y, Sfeir AJ, Zou Y, Buseman CM, Chow TT, et al. Telomere extension occurs at most chromo- some ends and is uncoupled from fill-in in human cancer cells. Cell 2009; 138: 463-75.
  • 2Dai X, Huang C, Bhusari A, Sampathi S, Schubert K, et al. Molecular steps of G-overhang generation at human telomeres and its function in chromosome end protection. EMBO J 2010; 29: 2788-80!.
  • 3Wu P, van Overbeek M, Rooney S, de Lange T. Apollo contributes to G overhang maintenance and protects leading-end telomeres. Mol Cell Mol Cell 2010 Jul 7. [Epub ahead of print].
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