摘要
目的研究冬凌草甲素自微乳对H22移植性肿瘤模型小鼠的肿瘤抑制作用。方法采用昆明小鼠接种肝癌H22瘤株造成相应的移植性荷瘤小鼠模型,以实体瘤模型小鼠的瘤重、抑瘤率观察冬凌草甲素自微乳对小鼠移植性肿瘤H22的抑制作用;以胸腺指数、脾脏指数为指标观察冬凌草甲素自微乳对免疫器官的影响;以小鼠平均生存时间观察冬凌草甲素自微乳对腹水瘤模型小鼠的生命延长作用。结果冬凌草甲素自微乳能有效地抑制实体瘤模型荷瘤小鼠体内肿瘤的生长,低、中、高(67,100,150 mg.kg-1)3个剂量组的抑瘤率分别为:43.94%、54.65%、59.57%;冬凌草甲素自微乳给药组小鼠胸腺指数和脾脏指数与荷瘤对照组相比,无显著性差异;中剂量(100 mg.kg-1)冬凌草甲素自微乳对腹水瘤肿瘤模型小鼠的生存时间具有延长作用,与荷瘤对照组相比具显著性差异。结论冬凌草甲素自微乳对荷瘤小鼠肿瘤生长具有一定的抑制作用,抑制作用强于冬凌草甲素,并有剂量依赖性。
Objective To study the anti-tumor effect of oridonin self-microemusifying drug delivery system（ORI-SMEDDS） on mouse H22 hepatocellular carcinoma in vivo.Methods KM mice bearing H22 tumor cells were used in this study.The anti-tumor activity of ORI-SMEDDS on solid tumor mice was evaluated by tumor mass weight and tumor inhibitory ratio,and the life-prolongation effect on ascitic tumor mice was assessed by average survival time.The influence on the immune organs was evaluated by the indexes of thymus and spleen of mice with transplanted tumor.Results ORI-SMEDDS had significant inhibiting effect on transplanted tumor growth in mice.Inhibitory rates of ORI-SMEDDS in the dosages of 67,100,150 mg·kg^-1 on H22 mice were 43.94 %、54.65 %、and 59.57 %,respectively.The differences of indexes of thymus and spleen were insignificant between the ORI-SMEDDS group and model control group.ORI-SMEDDS in the dosage of 100 mg·kg-1 had an effect on prolonging the life of mice with transplanted tumor,the statistical difference being significant as compared with the model group.Conclusion ORI-SMEDDS shows certain inhibition on the growth of transplanted H22 tumor with dose-dependence,and the inhibitory effect is stronger than oridonin.
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2010年第6期567-569,共3页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
上海市科委纳米专项(0852nm05300)
上海市优秀学科带头人计划资助(10XD1403900)
关键词
冬凌草甲素
自微乳
肿瘤抑制作用
肝癌H22细胞株
Oridonin
Self-microemusifying delivery system
Anti-tumor activity
H22 hepatocellular carcinoma
