摘要
目的观察甲基强的松龙(甲强龙)冲击治疗小儿肾病综合征的疗效与不良反应。方法回顾性分析小儿肾病综合征的临床资料,甲强龙组(28例)与泼尼松组(24例),分别予甲强龙冲击与泼尼松诱导缓解,两组尿蛋白转阴后继以口服泼尼松维持及减量常规治疗1～2年。观察两组患儿的疗效与不良反应。结果甲强龙组达完全缓解时间(7.48±1.09)d明显短于泼尼松组(9.65±2.32)d(P<0.01),完全缓解率(68.4%)及总缓解率(93.1%)均明显高于泼尼松组(P<0.01)。甲强龙组治疗1周内不良反应总发生率(50.0%)明显高于泼尼松组(20.8%),治疗3个月时腹部皮下脂肪厚度低于后者。结论甲强龙冲击治疗小儿肾病综合征起效较快,中期不良反应稍低于常规泼尼松治疗,但冲击治疗期间不良反应较多。
Objective To investigate the effect and adverse reactions of methylprednisolone pulse therapy in children with nephrotic syndrome. Methods A retrospective analysis was made of the clinical data of children with nephrotic syndrome. The patients in methylprednisolone group （28 cases） and prednisone group （24 cases） were treated with methylprednisolone and prednisone to induce remission, respectively. The conventional oral prednisone therapy was followed for 1- 2 years after urinary protein became negative in the two groups. The effects and adverse reactions were observed. Results The methylprednisolone group（7.48 ± 1.09） days was shorter than the prednisone group （9.65 ±2.32）days in reaching complete remission （P〈0.01）. The complete remission rate （68.4%） and the overall response rate （93.1%） in the methylprednisolone group were significantly higher than those in the prednisone group （P〈0.01）. The overall incidence of adverse reactions（50.0%） after one week in the methylprednisolone group was significantly higher than that in the prednisone group （20.8%）, but the abdominal subcutaneous fat thickness in the former was less than that in the latter after 3-month treatment. Conclusion Methylprednisolone pulse therapy in children with nephrotic syndrome shows a rapid effect, and slightly fewer adverse reactions than those in the conventional prednisone therapy during medium-term treatment, with more adverse reactions during pulse therapy.
出处
《中国现代医生》
2010年第33期60-61,102,共3页
China Modern Doctor
