摘要
目的:研究促胃泌素释放肽(gastrin-releasing peptide,GRP)与自然流产的关系,进一步探讨GRP在妊娠过程中所起的作用。方法:建立小鼠正常妊娠模型(对照组)和自然流产模型(实验组),于妊娠13.5 d计算胚胎吸收率;采用免疫组织化学法测定各组GRP的表达情况。结果:实验组孕鼠的胚胎吸收率明显高于对照组,差异显著(P<0.05)。实验组的GRP表达率明显低于对照组,差异有统计学意义(P<0.05)。结论:GRP参与正常妊娠过程,自然流产的发生可能与GRP的低表达有关。
Objective： To investigate the relationship of GRP and spontaneous abortion.Methods： The normal pregnant model（control group） and spontaneous abortion model（the experimental group） were performed.The embryo resorption rate was calculated on day 13.5 of gestation and the expression of GRP was detected by using immunohistochemical methods.Results： The embryo resorption rate in the experimental group was significantly increased in comparison with that in the control（P0.05）,and the expression of GRP in the experimental group was significantly reduced in comparison with that in the control（P0.01）.Conclusion： The GRP participates in the procedure of normal pregnancy,and the lower experssion of GRP may lead to the spontaneous abortion.
出处
《生殖与避孕》
CAS
CSCD
北大核心
2010年第10期665-667,共3页
Reproduction and Contraception
关键词
自然流产
GRP
免疫组织化学
小鼠
spontaneous abortion
GRP
immunohistochemical methods
