摘要
目的探讨游离前列腺特异性抗原和总前列腺特异性抗原比率（Ｆ／ＴＰＳＡ）对前列腺疾病临床诊断的意义。方法用微粒子捕捉酶免分析法（ＭＥＩＡ），检测前列腺增生症６６例、前列腺癌１５例及正常组６０例的血清ＦＰＳＡ、ＴＰＳＡ浓度及其比率，所得数据进行统计学分析。结果前列腺癌组ＦＰＳＡ／ＴＰＳＡ平均比率为７．１８％，前列腺增生组平均为１９．８７％，正常对照组为３１．８２％。结论前列腺癌病例ＦＰＳＡ／ＴＰＳＡ比率均小于１０％，因此，ＦＰＳＡ／ＴＰＳＡ比率可更有效地诊断前列腺癌，当ＴＰＳＡ浓度为小于２０ｕｇ／ｌ时，测定其比率有相当大的临床意义。
Objective To explore the
diagnostic value of free prostate-specific antigen(F-PSA) /total PSA(T-PSA) for prostatic
diseases.THZ Methods Serum levels of F-PSA and T-PSA in 66 patients with benign
prostatic hyperplasia (BPH) 15 prostatic cancer (PCa) and 60 healthy individuals were
measured by microparticle enzyme immunoassay (MEIA), calculated F/T PSA ratio. Results
The average F/T PSA ratio were 7.18%19.87% and 31.82%, respectively in PCaBPH and control
group. Conclusion The F/T PSA was less than 10% in PCa patients,so PCa could be
diagnosed in those with low F/T PSA value. In case of T-PSA<20g/l, measuring of F/T PSA had
its special clinical value.
