摘要
本研究观察５６例丙肝患者（急性２７例，慢性２９例）ＰＢＭＣ经ＰＨＡ刺激后的ｍＩＬ－２Ｒ表达和血清ｓＩＬ－２Ｒ水平，设健康对照组３０例。结果：⑴丙肝患者ｍＩＬ－２Ｒ表达较低，急、慢性之间差异无显著性；⑵丙肝患者血清ｓＩＬ－２Ｒ水平较高，急性组高于慢性组；⑶丙肝患者ｍＩＬ－２Ｒ表达和血清ｓＩＬ－２Ｒ水平之间无明显关系。表明ｍＩＬ－２Ｒ表达不足和ｓＩＬ－２Ｒ水平升高在丙肝患者机体免疫抑制机制中起重要作用；
The expression of mIL-2R in PBMC and level of sIL-2R after PHA stimulation were determined by indirect immunofluorescence technique and double antibody sandwich ELISA method,respectively. The results were as follows:⑴mIL-2R expression in the patients ( n =56) was lower than that in the normal control ( n =30)。⑵All the patients with hepatitic C have shown high serum sIL-2R levels and acute patients was higher than in the chronic patients.⑶The definite relation was not found between the expression of mIL-2R in PBMC and serum sIL-2R level.⑷These results indicated that insufficient of mIL-2R expression and abnormal increase of sIL-2R level could play important roles in the immunodepression of patiemts with hepatitis C.The determination of mIL-2R,in especially,sIL-2R may provide a useful clinical indicator for judging disease activity.
出处
《中国医师杂志》
CAS
1999年第6期22-23,共2页
Journal of Chinese Physician
关键词
白细胞介素2
受体
丙型肝炎
Hepatitis C Soluble interleukin-2 receptor Membranous interleukin-2 receptor
