摘要
目的:探讨药品不良反应(ADR)发生的特点及规律。方法:采用描述性研究方法,对我院2008年1月～2009年12月上报的93例头孢菌素类药物ADR报告进行统计、分析。结果:皮试液的选择有3种情况,分别为采用1种头孢菌素类药物皮试,采用拟用品种(原数)进行皮试、不作皮试或用其它药物皮试。涉及ADR的头孢菌素类药品共18个,发生频率排在前3位的是头孢哌酮/舒巴坦、头孢哌酮和头孢替安。ADR的主要临床表现以皮肤及其附件损害为主,有72例(77.42%)。结论:临床应规范皮试液的选择;重视ADR监测与报告、定期分析报告数据,为临床及时提供药品安全信息,以减少或避免ADR的重复发生。
OBJECTIVE：To investigate characteristics and regularity of cephalosporin-induced adverse drug reaction（ADR）.METHODS：In descriptive study,93 cases of cephalosporin-induced ADR in our hospital from Jan.2008 to Dec.2009 were analyzed statistically.RESULTS：There were 3 kinds of situations for the selection of skin test solution,i.e adopting one kinds of cephalosporin skin test solution for skin test,adopting proposed skin test solution,no skin test or adopting other drugs.18 kinds of cephalosporin drugs were involved in the ADR reports,and the top 3 skin test solutions in the list of the incidence of ADR were cefoperazone/sulbactam,cefoperazone and cefotiam.The injury of skin and its appendants were the main clinical manifestations（72 cases,77.42%）.CONCLUSION：The selection of skin test solution should be standardized in the clinic.Great importance should be attached to ADR monitoring and reporting,and regular data analysis.Drug safety information should be provided timely so as to reduce or avoid the recurrence of ADR.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第44期4191-4193,共3页
China Pharmacy
关键词
头孢菌素
皮试液
药品不良反应
报告
分析
Cephalosporin
Skin test solution
Adverse drug reaction（ADR）
Reports
Analysis
