摘要
研究利用快速、温和、有效的生物矿化方法制备了壳聚糖纳米羟基磷灰石杂化海绵材料。在矿化过程中使用乙醇-水混合溶剂来控制纳米羟基磷灰石晶体的相变、生长及形态,利用尿素的分解来控制体系的pH值。通过XRD、TEM、FT-IR和SEM对海绵结晶、组成及形貌进行了表征,通过压缩强度测试检测了矿化前后海绵的力学强度变化。结果表明高结晶度和取向度的羟基磷灰石晶体能够迅速有效地沉积在壳聚糖海绵的表面,并且力学强度显著提高,压缩强度和压缩模量分别达到(2.42±0.006)和(29.29±1.25)MPa。本矿化方法可以推广到其它天然生物材料及器械的生物矿化。
Mineralization of biopolymers is a hot topic and a promising method for tissue engineering.In this study,biomimetic mineralization of chitosan sponges was performed in a large quantity with a rapid and facile approach.The calcium phosphate apatite was co-precipitated as the precursor for the formation of hydroxyapatite in mixed water-ethanol solution.The component and morphology of the apatite and the nanocomposite hybrid sponges were measured with XRD,TEM,FTIR and ESEM.Results revealed that chitosan matrix improved the crystalline quality of hydroxyapatite（HAP）crystals.With elongation of mineralization time,the mineral layers on the outer surface and inner section of chitosan sponges increased.The chitosan sponge or the microenvironment around it promoted the crystallites quality of HAP phase.Furthermore,the compressive strength and modulus of the HAP-chitosan bio-composites increased to 0.55 MPa and（29.29±1.25）MPa respectively.Such onepot approach might be extended to the mineralization of other biopolymers and will have a very broad application in the future.
出处
《功能材料》
EI
CAS
CSCD
北大核心
2010年第11期1955-1958,共4页
Journal of Functional Materials
基金
国家高技术研究发展计划(863计划)资助项目(2007AA091603)
国家自然科学基金资助项目(30900307)
教育部博士点基金资助项目(200805590001)
