摘要
目的··：了解阿片对人体产生的细胞遗传学效应。方法··：运用微量人全血培养方法研究了阿片滥用者的外周血淋巴细胞染色体畸变、微核形成及细胞分裂指数。结果··：滥用阿片能够诱发人血淋巴细胞染色体畸变，提高微核形成率，并可使细胞分裂指数下降。随着滥用史的延长，其损害作用具有显著增加的趋势。结论··：阿片是人血淋巴细胞染色体的损伤因子。
Objective: To study cytogenetics effect of the opiate on human body. Method: Use human whole blood culture to study the chromosomal aberration of opiate addicts, lymphocyte, lymphocytes micronucleus frenquency and mitotic index. Result: Abusing opiate induced human chromosomal aberration, increased lymphocytes micronucleus frenquency and declined mitotic index. With the increase of addiction history, the damage of hereditary materials had an obvious increasing trend. Conclusion:Opiate injures human blood lymphocyte chromosome.
出处
《中国药物依赖性杂志》
CAS
CSCD
1999年第2期110-112,共3页
Chinese Journal of Drug Dependence
关键词
阿片
微核率
染色体畸变
细胞分裂指数
opiate
lymphocyte
micronucleus
chromosomal aberration
mitotic index
