摘要
以硝普钠作一氧化氮供体，观察不同剂量一氧化氮存在条件下ＨＳＶ１在ＨｅＬａ细胞和ＶｅｒｏＥ６细胞中增殖情况。结果表明：一氧化氮对ＨＳＶ１在ＶｅｒｏＥ６细胞中增殖有明显抑制作用，而对ＨＳＶ１在ＨｅＬａ细胞中增殖无明显影响。提示一氧化氮的抗病毒作用存在着细胞敏感性差异。
The effects of nitric oxide(NO) on HSV 1 infection of HeLa cell line and Vero E6 cell line were investigated in this study. The titers of HSV 1 in supernatants from infected culture of Vero E6 cells were decreased by a NO donor, sodium nitroprusside(SNP), in a dose dependant manner, while the control compound potassium ferricyanide(KFC) had no effect. However, SNP had no effect on that of HeLa cells. The results reaffirm the antiviral effect of NO and suggest that the susceptibility of different cell lines to the effect of NO might be varied.
出处
《湖南医科大学学报》
CSCD
1999年第2期110-112,共3页
Bulletin of Hunan Medical University
