摘要
1例64岁男性,为美容在眼角和前额部多点注射肉毒素A除皱,每点约2～5U,总剂量<50U。注射后1h出现头晕、心悸、颜面部红肿、睁眼困难、腹痛、腹泻和轻微呼吸困难。T36.7℃,R20次/min,P56次/min,BP120/75mmHg。考虑为肉毒素A过敏反应,立即给予地塞米松、西咪替丁、维生素C、苯海拉明及左西替利嗪抗过敏治疗,约1h后颜面肿胀和呼吸症状缓解,腹痛、腹泻症状消失。第2天,再次静脉滴注地塞米松,患者病情进一步好转。
A 64-year-old man received injections of botulinum toxin A at multiple points on his canthi and forehead in the treatment of wrinkles for a cosmetic purpose.Botulinum toxin A 2-5 U was injected into each point and the total dosage was 50 U.One hour after injection,the patient developed dizziness,palpitation,facial swelling with flushing,difficulty in eye opening,abdominal pain,diarrhea,and mild dyspnea,with a temperature of 36.7 ℃,a respiratory rate of 20 breaths/min,a pulse of 56 beats/min,a BP of 120/75 mm Hg.The case was considered to be botulinum toxin A-induced anaphylaxis,and dexamethasone,cimetidine,vitamin C,diphenhydramine and cetirizine were given immediately.One hour later,his facial swelling and dyspnea relieved,and abdominal pain and diarrhea disappeared.The next day,the patient received an IV infusion of dexamethasone again,and his condition improved further.
出处
《药物不良反应杂志》
2010年第5期360-361,共2页
Adverse Drug Reactions Journal
关键词
肉毒素
不良反应
过敏反应
botulinum toxin A
adverse reactions
allergic reaction
