摘要
目的研究慢性肾功能衰竭（ＣＲＦ）患者氧自由基损伤情况。方法测定８０例ＣＲＦ患者和３０例正常人血清ＬＰＯ含量、总ＳＯＤ、ＣｕＺｎ—ＳＯＤ、Ｍｎ—ＳＯＤ活性水平。结果ＣＲＦ患者血清ＬＰＯ含量、总ＳＯＤ、ＣｕＺｎ—ＳＯＤ、Ｍｎ—ＳＯＤ活性均较正常人明显增高（Ｐ＜００５～００１），且总ＳＯＤ、ＣｕＺｎ—ＳＯＤ、Ｍｎ—ＳＯＤ活性与Ｓｃｒ呈显著正相关，与ＧＦＲ呈显著负相关。结论①ＣＲＦ患者存在氧自由基的蓄积，脂质过氧化反应病理亢进和超氧化物歧化酶代偿性增高的病理改变；②血ＳＯＤ活性可作为反映肾功能损害的可靠指标。
Objective Our aim is to research the change of the OFR
metabolism in CRF patients.Methods The concentration of serum lipid peroxide (LPO) and the
activities of serum total superoxide dismutase(T-SOD),including CuZn-SOD、Mn-SOD were
measured in 80 cases of CRF patients and 30 healthy persons.Results ①The values of LPO、
T-SOD、CuZn-SOD、Mn-SOD in CRF patients were increased significantly( P <0 05～0 01);
②The serum concentration of creatinine(Scr)was positivelycorrelated to the activities of
T-SOD、CuZn-SOD、Mn-SOD;Glomerular filtration rate(GFR)was negatively correlated to the
activities of T-SOD、CuZn-SOD、Mn-SOD.Conclusion ①This study indicate the abnormality of
oxygen free radical reaction and high activity of SOD present in CRF patients.②The activities of
serum SOD may be regarded as an objective index for the degree of renal damage. [
出处
《中国急救医学》
CAS
CSCD
北大核心
1999年第3期155-156,共2页
Chinese Journal of Critical Care Medicine
