摘要
目的了解山莨菪碱对家兔急性全脑缺血再灌注期间兴奋性氨基酸释放及生存状况的影响。方法５６只家兔采用“闭塞双侧颈总动脉和椎动脉＋体循环低血压法”建立急性全脑缺血再灌注损伤模型。观察山莨菪碱（Ａｎｉ）对缺血再灌注期间脑组织兴奋性氨基酸（ＥＡＡ）含量及动物生存状况的影响。结果Ａｎｉ可降低脑组织ＥＡＡ含量的下降幅度，提高动物２４ｈ生存率，降低神经功能缺陷评分。结论Ａｎｉ可抑制ＥＡＡ过度释放，改善缺血再灌注脑损伤动物的生存状况，在临床脑复苏中可能有一定的应用前景。
Objective To find out the effects of anisodamine on the release of excitatory amino acid and survival condition after a cute brain damage following complete cerebral ischemia and reperfusion in the rabbit.Methods The model of acute brain damage following complete cerebral ischemia and reperfusion was established in fifty six rabbits by ligation of bilateral carotids and vertebral arteries with systemic hypotension. By observing the effects of Anisodamine (Ani) on the content of excitatory amino acid (EAA) in brain tissues and survival condition in the duration of complete cerebral ischemia and reperfusion, the following results were found:with the use of Ani, the decline in the content of EAA was inhibited. Moreover, there were a increase in survival rate for twenty-four hours and a decrease in neurologic deficit score (NDS).Results We suggested that the use of Ani as early as possible can inhibit the overrelease of EAA and improve the survival condition after acute brain damage following complete cerebral ischemia and reperfusion.Conclusion We conclude that Ani is possibly good for clinic cerebral resuscitation if it is properly used. [
出处
《中国急救医学》
CAS
CSCD
北大核心
1999年第3期133-135,共3页
Chinese Journal of Critical Care Medicine
关键词
脑脑血
再灌注损伤
氨基酸
山莨菪碱
家兔
Anisodamine Excitatory amino acid Survival rate Neurologic deficit score Complete cerebral ischemia and reperfusion
