摘要
目的研究立体定向放射治疗序贯TP方案化疗治疗不能手术的早期非小细胞肺癌疗效和毒副作用。方法 60例不能手术的早期非小细胞肺癌患者随机分成A组和B组进行临床研究,A组30例采用立体定向放射治疗,剂量(50%剂量线)4～5Gy/次,隔日1次,共8～10次,总剂量40～50Gy。B组30例采用立体定向放射治疗序贯TP方案化疗四个疗程。结果两组患者的总有效率分别为80.0%(24/30)和83.3%(25/30),P>0.05,患者1、2年总生存率分别为86.7%(26/30)VS83.3%(25/30)和73.3%(22/30)VS80.0%(24/30),P>0.05。2年无远处转移生存率分别为60.0%(18/30)和73.2%(22/30),B组虽高于A组,但P>0.05。两组患者早期放射反应主要为I^II级放射性肺炎和骨髓抑制,后期放射反应主要为I^II级放射性肺炎,发生率两组接近。结论立体定向放射治疗序贯TP方案化疗治疗不能手术的早期非小细胞肺癌疗效较好。
Objective To evaluate the therapeutic efficacy and the radiation complication of stereotactic radiotherapy sequence TP in patients with inoperable early stage non-small-cell lung cancer （NSCLC）. Methods 60 patients with inoperable early stage NSCLC were randomly divided into two groups. The 30 patients in group A received stereotactie radiotherapy. Dosage（50%） to the total dose of 40 - 50 Gy with 4 - 5 Gy per fraction treated every other day, 8 - 10 times. The 30 patents in group B received stereotactic radiotherapy sequence TP 4 cycles. Results The efficacy rates in group A and B were 80.0% and 83.3%, without significant difference （p 〉0.05）. The one and two year survival rates of the patients in group A and B were 86.7% （26/30） VS 83.3% （25/30）, 73.3% （22/30） VS 80.0% （24/30） respectively, without significant difference （p 〉0.05）. The two year non-metastasis survival rates were 60.0% （18/30） and 73.2% （22/30） respectively, the group B was better than group A, but without significant difference （p 〉0.05）. The major acute radiation complication observed in the two groups were grade I to II radiation pneumonitis and hematopoietic toxicity. The later radiation complication in the two groups were grade I to II radiation lung fibrosis, without significam difference. Conclusion The efficacy of stereotactic radiotherapy sequence TP is better than stereotactic radiotherapy in patients with inoperable early stage NSCLC.
出处
《临床医学工程》
2010年第11期5-7,共3页
Clinical Medicine & Engineering
基金
广东省医学科研基金资助(A2007319)
