摘要
在室温下,采用十二烷基硫酸钠(SDS)-聚乙烯吡咯烷酮(PVP)二元体系为反应模板,合成得到了纳米羟基磷灰石(HAP)。通过透射电镜、X射线衍射、红外光谱等方法对产品进行表征,结果表明:所得产品为六方晶系的纳米HAP,产品尺寸形貌均一,为50 nm×2 nm的针状结构。由于使用的模板生物安全性良好,所得纳米HAP尺寸又较小,因此本方法是制备生物医学工程领域所需纳米HAP的新方法。采用对乙酰氨基酚为药物负载对象的研究表明,纳米HAP负载药物后,经12 h药物释放率方达到94.4%,能够有效地起到药物缓释的作用。
Using sodium dodecyl sulfate（SDS）-polyvinylpyrrolidone（PVP） as soft template,nano hydroxyapatite（HAP） was prepared at room temperature.The nanoparticles were characterized by TEM,XRD and IR.The results showed that the products were needle-like nanoparticles with uniform morphology and their sizes were about 50 nm×2 nm.These HAP crystals belonged to hexagonal system.As this template had good biosecurity and the size of the product was small,this method was suitable to synthesize nano HAP using at biomedical engineering field.Acetaminophen was used to test the medicine delayed-release property of the nano HAP.The results showed that with acetaminophen loading onto the nano HAP,after 12 h,the medicine release percentage was only 94.4%.The effect of medicine release was obvious.
出处
《江南大学学报（自然科学版）》
CAS
2010年第5期586-591,共6页
Joural of Jiangnan University (Natural Science Edition)
基金
国家自然科学基金项目(20871059)
江南大学校内科学研究基金项目(2009LYY04)
中央高校基本科研业务费专项基金项目(JUSRP20905)
关键词
羟基磷灰石
聚乙烯吡咯烷酮
十二烷基硫酸钠
软模板
药物缓释
Hydroxyapatite
polyvinylpyrrolidone
sodium dodecyl sulfate
soft template
medicine delayed-release
