摘要
目的观察ＶＥ对ＡＤ大鼠海马β－ＡＰＰ表达的影响。方法使用三氯化铝诱导建立ＡＤ模型大鼠。用ＶＥ（１０ｍｇ／ｄ／只）对ＡＤ模型大鼠进行灌胃治疗３月。采用行为测试，光镜免疫细胞化学ＡＢＣ法，观测大鼠海马结构淀粉样前体蛋白反应阳性神经元的数目和β－淀粉样前体蛋白表达的变化。结果ＶＥ组大鼠受电击次数和潜伏期较对照组明显减少和延长（Ｐ＜０．０５）；ＶＥ组大鼠海马结构齿状回和ＣＡ１区淀粉样蛋白反应阳性神经元的数目较对照组均有明显减少（Ｐ＜０．０５），β－淀粉样前体蛋白呈弱阳性表达。结论ＶＥ可以改善ＡＤ模型大鼠的学习记忆，降低海马结构β－淀粉样前体蛋白过度表达。
The
model of dementia was established by pretreatment with aluminium chlorid, PO. After treating
with vitamin E for two monthis. The alternation of rat's behaviour and the expression of β APP
in hippocampal structure was observed with behaviour test and ABC immunocytochemical
method. The results showed that the frequency of electric shock was decreased, incubation
period was prolonged, the number of APP Li neuron in CA1 region and dentate gyrus was
decreased, there were significant difference between VE group and control group (P<0 01) ,It is
suggested that VE could improve the learning and memorizing abilities of AD model rats and
prevent β APP overexpression in hippocampal structure.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
1999年第4期234-234,共1页
Chinese Journal of Gerontology
基金
国家自然科学基金
