摘要
目的测定血管活性肠肽(VIP)、白介素(IL)-5和组胺在慢性特发性荨麻疹(CIU)患者血清中的水平,初步探讨神经精神因素在CIU发病中的作用。方法应用ELISA法测定46例CIU患者及34例正常人血清VIP,IL-5和组胺的含量,并进行比较分析。结果 CIU组血清中VIP,IL-5和组胺的含量高于正常对照组(P<0.05)。CIU组血清VIP与组胺水平成正相关(P<0.05),VIP与IL-5及IL-5与组胺之间无相关性(P均>0.05)。结论 VIP可能通过组胺释放而诱发或加重CIU,神经精神因素可能通过此途径导致CIU的发生和发展。
Objective In order to determine the role of neuropsychiatric factors in the pathogenesis of Chronic Idiopathic Urticaria （CIU）. Methods ELISA method was used to detect VIP,IL-5 and histamine in the serum of 46 patients of CIU and 34 normal people. Results The serum level of VIP, IL-5 and histamine in CIU group were higher than that in control group（ P 〈 0.01 ）. The serum level of VIP and histamine in CIU group were positive corretated（ P 〈 0.05 ）. There was no correlation between the serum level of VIP and IL-5 （P 〉 0.05） and the serum level of IL-5 and histamine（ P 〉 0.05 ）. Conclusion Histamine could induce or aggravate CIU by releasing VIP,and neuropsychological factors may lead the occurrence and relapse of CIU in this way.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2010年第11期1014-1016,共3页
The Chinese Journal of Dermatovenereology
基金
山东省青岛市科技发展计划项目基金(Kzd-33)
