摘要
目的 丝氨酸蛋白酶抑制剂A3基因（SERPINA3）已被证明与芬兰白种人颅内动脉瘤的发病机制相关,在中国汉族颅内动脉瘤患者中检测与分析SERPINA3基因rs4934位点多态性.方法 利用聚合酶链式反应-TaqmanMGB探针方法,比较275例散发性颅内动脉瘤（50.83±10.78）岁和361例正常对照（53.21±10.81）岁之间SERPINA3基因rs4934位点的基因型及等位基因频率的构成.结果 在动脉瘤组和对照组之间SERPINA3基因rs4934位点的基因型及等位基因频率分布差异无统计学意义,用logistic回归纠正性别和年龄因素结果没有改变.结论 在中国汉族人群中颅内动脉瘤和对照组之间SERPINA3基因rs4934位点多态性差异无统计学意义.
Objective Serine protease inhibitor member 3 of clade A （SERPINA3） gene on chromosome 14o32. 1 has been showed to be associated with intracranial aneurysms in a Polish population. In this study, the purpose was to test and analyze the polymorphism of the SERPINA3 in intracranial aneurysms in Chinese Hah nationality. Method To compare the genotype frequency and A allele frequency of rs4934polymorphism of the SERPINA3 in 275 patients with intracranial aneurysms and 361 controls by polymerase chain reaction and Taqman MGB probe analysis. Results The GA ＋ AA genotype frequency of rs4934 polymorphism of SERPINA3 of aneurysm group （85. 1%）was no much higher than that of control group （81.44%） （χ2 = 1.475,P = 0.224）. The A allele frequency ofaneurysm group （58.55%） was also no higher than the control group （59. 14%）（χ2 = 1.445, P = 0. 229）. Adjustment for age, sex using logistic regression did not change the results （χ2 = 1. 499, P = 0. 221 ）. Conclusions There is no significant difference of the rs4934 polymorphism of SERPINA3 between intracranial aneurysms and controls among individuals of Chinese Han nationality.
出处
《中华神经外科杂志》
CSCD
北大核心
2010年第10期888-890,共3页
Chinese Journal of Neurosurgery
基金
基金项目：国家自然科学基金（30973109）
山东省科技厅科技攻关重点项目（2004GG2202140）
