摘要
实验表明,维生素甲可减少小鼠的诱发性大肠癌,但其毒性较大而使用受限。国内徐世平等通过改变维甲酸的末端基团,合成了一系列维甲酸的酰胺和酯,其中N-(4-乙氧羰基苯基)维生素甲酰胺[N-(4-Etho-xycarbophenyl)Retinamide](简称维胺酯或RI)毒性较低,对化学诱发小鼠前胃上皮增生与癌变有较明显的抑制作用。本文研究了RI对DMH诱发小鼠大肠癌的保护作用,并对其作用原理进行初步探讨。
The effects of RI on mice colon cancer induced by DMH were studied. The results showed that the incidence of colon cancer was 40.5% (15/37) in the preventive group and 63% (17/27) in the DMH controls, and the incidence of precancer attack was 21.6% (8/37) and 37% (10/27) resp- ectively. The rate of cancer inhibition of RI group was 35.7% (P<0.01). Under the electronic microscope cell differentiation was observed in the preventive group. The radioactivity was 564± 81 in the preventive group, and 841±208 in the controls (P<0.01). The weight of thymus of the mice was 63±16 mg in the preventive group and 44±13 mg in the controls (P<0.01). RI has some preventivo effect on mice colon cancer induced by DMH, and the mechanism probably lies in its action on the promotion of cell differentiation and inhibition of DNA synthesis in cancer cells as well as its function to enhance the immunity of the body.
出处
《实用肿瘤杂志》
CAS
北大核心
1990年第3期162-165,共4页
Journal of Practical Oncology
