摘要
目的:探讨干扰素联合中药治疗慢性乙肝的疗效。方法:选择136例慢性乙型肝炎患者,随机分为A,B两组,其中A组为干扰素治疗组56例,B组为干扰素联合中药组80例。a-干扰素500万U肌肉注射,隔日1次,疗程12个月,中药1剂/d,疗程12个月。观察患者肝功能.HBV-DNA及血清病毒指标。结果:治疗结束时,A组患者ALT复常率为55.0%,HBeAg阴转率为40.3%,HBV-DNA阴转率为30.2%,HBeAg抗/HBe转换率为14.0%;B组ALT复常率为90.0%,HBeAg阴转率为61.2%,HBV-DNA阴转率为76.2%,HBeAg抗/HBe转换率为26.5%。两组之间有统计学差异(P<0.05)。结论:中药本身不仅具有一定的抗病毒作用,而且针对干扰素治疗过程中产生的不良反应起到一定的治疗作用,更重要的是针对干扰素治疗间歇期的病毒有抑制作用。
Objective：To investigate the influence of interferon alfa -2b combined with Chinese medicine on chronic hepatitis. Methods：A total of 136 cases with chronic hepatitis were randomly divided into two groups. In group A, patients were treated by interferon alfa -2b, and in group B ,the patients were received by interferon alfa -2b combined with Chinese medicine. One year later, the curative efficacy of all patients was evaluated and compared between the two groups including hepatia,HBV -DNA,ah. Results： Compared wtih the both groups, in A group, ALT recovery ratio was 55% , HBeAg translate negative ratio was 40. 3% ,HBV - DNA was 30.2% ,HBeAg/anti - HBe transtiou ratio was 14% ,while in B group,ALT recovery ratio was 90% , HBeAg translate negative ratio was 61.2% , HBV - DNA was 76.2% , HBeAg/ anti- HBe transtion ratio was 26. 5%. There were significant different between both groups（P 〈 0. 05）. Conclusions： Chinese medeine not only have antiviral effect but also cure interferon, s side effect, what, s more, it can inhibit viral reduplication during the treatment of the interval period.
出处
《航空航天医药》
2010年第10期1765-1766,共2页
Aerospace Medicine
关键词
乙型肝炎
A-干扰素
中药
Chronic hepatitis
Alfa - 2b
Chinese medicine
