期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

叶酸和同型半胱氨酸在神经系统发育中的作用研究进展

原文传递
导出
摘要 神经系统的正常发育需要含叶酸饮食,叶酸在调控神经生成和程序性细胞死亡中起重要作用。近年来的流行病学和实验研究发现,叶酸缺乏和伴随其后的血中同型半胱氨酸水平增高在神经系统发育中可影响神经可塑性,从而导致神经退行性病变。本文对叶酸和同型半胱氨酸在神经系统发育中的作用研究作出综述。
作者 倪锦 江艳芳 古妙宁
机构地区 广州市妇女儿童医疗中心麻醉科 广州市妇女儿童医疗中心营养室 南方医科大学附属南方医院麻醉科
出处 《中国儿童保健杂志》 CAS 2010年第11期862-864,共3页 Chinese Journal of Child Health Care
基金 广州市医药卫生科技项目(2007-YB-060) 广州市中医药科研项目(2009-A-26)
关键词 叶酸 同型半胱氨酸 神经系统 发育
分类号 R722 [医药卫生—儿科]
  • 相关文献

参考文献13

  • 1高光清,卢晓琳,白继保,白春林.妊娠神经管畸形孕妇血清叶酸与同型半胱氨酸水平分析[J].中国妇幼保健,2010,25(14):1903-1905. 被引量：17
  • 2Simmi K. Ratan,Kamal Nain Rattan,Ravindra Mohan Pandey,Savita Singhal,Simmi Kharab,Manju Bala,Veena Singh,Atul Jhanwar.Evaluation of the levels of folate, vitamin B12, homocysteine and fluoride in the parents and the affected neonates with neural tube defect and their matched controls[J]. Pediatric Surgery International . 2008 (7)
  • 3Engeham SF,Haase A,Langley-Evans SC.Supplementa-tion of a maternal low-protein diet in rat pregnancy withfolicacid ameliorates programming effects upon feeding behaviourin the absence of disturbances to the methionine-homocys-teine cycle. British Journal of Nutrition . 2010
  • 4Couto FD,Moreira LM,Dos Santos DB,et al.Folate,vita-min B12 and total homocysteine levels in neonates from Bra-zil. European Journal of Clinical Nutrition . 2007
  • 5Casella EB,Valente M,de Navarro J M,et al.Vitamin B12deficiency in infancy as a cause of developmental regression. Brain and Development . 2005
  • 6Malaguarnera M,Ferri R,Bella R,et al.Homocysteine,vitamin B12 andfolatein vascular dementia andin Alzhei merdisease. Clinical Chemistry and Laboratory Medicine . 2004
  • 7ND Greene,P Stanier,AJ Copp.Genetics of human neural tube defects. Human Molecular Genetics . 2009
  • 8Amorim MR,Castilla EE,Orioli IM.Is there a familial linkbetween Down’s syndrome and neural tube defects? Population and familial survey. British Medical Journal . 2004
  • 9E H Reynolds.Benefits and risks of folic acid to the nervous system. Journal of Neurocytology . 2002
  • 10Folate deficiency induces neural stem cell apoptosis by increasing homocysteine in vitro. Journal of Clinical Biochemistry and Nutrition . 2009

二级参考文献8

  • 1Elwood JM, Elwood JH. Epidemiology and control of neural tube defects [M]. London: Oxford University Press, 1992:80.
  • 2Davidoff M J, Petrini J, Damus K,et al. Neural tube defect -specific infant mortality in the United States [ J ]. Teratology, 2002,66 ( Suppl 1 ) :S17.
  • 3Copp A J, Greene ND, Murdoch JN. The genetic basis of mammalian neurulation [J] .Nat Rev Genet, 2003, 4 (10): 784.
  • 4Steegers- Theunissen RPM, Boers GH, Trijbels JF, et al. Neural tube defects and derangement of homocysteine metabolism [ J ]. N Eng J Med, 1991, 324 (3): 199.
  • 5Finkelstein JD. Methionine metabolism in mammals [ J ]. J Nutr Biochem, 1990, 1 (5): 228.
  • 6Bohles H, Amdt S, Ohlenschlager U, et al. Maternal plasma homocysteine, placenta status and docosahexaenoic acid concentration in erythrocyte phospholipids of the newborn[J]. EurJ Pediatr,1999,158(3) .243.
  • 7Blom HI, Shaw GM, Den Heijer M, et al. Neural tube defects and folate: case far from closed[J]. Nat Rev Neurosci,2006,7(9) :724.
  • 8Kirke PN, Molloy AM, Daly LE, et al. Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects [J] . Q J Med, 1993, 86 (11): 703.

共引文献16

中国儿童保健杂志
2010年 第11期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部