摘要
鼻型结外自然杀伤（NK）-T细胞淋巴瘤（NKTCL）起源于成熟NK细胞或NK样T细胞，常表达CD3e和CD56，Epstein—Barr病毒（EBV）常阳性并在发病机制中起重要作用。已经建立了多种NKTCL的细胞株和动物模型并用于实验研究。NKTCL存在多种染色体畸变，最常见的是6q-，但无明显特异性。瘤细胞还存在多种基因表达异常及表观遗传学异常，为将来的靶向治疗提供了潜在的治疗靶点。
Nasal-type extranodal nature killer-T-cell lymphoma （NKTCL） originates from mature na- ture killer （NK） cell or NK-like T cell. This lymphoma cells are usually CD3g, CD56 and Epstein-Barr Virus （EBV） positive and the later plays an important role in the pathogenesis. A number of cell lines and animal models of NKTCL have been established and used in experimental studies. NKTCL always has various chromo- some aberrations and the most common is 6q- which are not specific for the disease. Various abnormalities in genes expression and epigenetic also have been found, which might provide potential targets for target therapy in the future.
出处
《国际肿瘤学杂志》
CAS
2010年第11期869-872,共4页
Journal of International Oncology
