摘要
目的比较西罗莫司药物洗脱支架和金属裸支架治疗冠心病患者的远期安全性。方法选择北京安贞医院2000年1月至2004年8月置入金属裸支架的冠心病患者505例,与2004年1月至2005年1月置入西罗莫司洗脱支架的984例冠心病患者进行历史性对照分析,比较两组患者支架术后随访2年的死亡、支架内血栓、非致死性心肌梗死发生率。结果两组患者在合并吸烟、高血压、高血脂、糖尿病所占比例及冠状动脉病变支数方面差异均无统计学意义。西罗莫司洗脱支架组患者平均年龄较大、分叉病变比例高、置入支架平均直径小且平均支架长度较长。临床随访2年,两组患者生存率、支架内血栓、非致死性心肌梗死及死亡/非致死性心肌梗死发生率方面差异均无统计学意义(分别为99.3%、1.3%、1.1%、1.8%和98.3%、1.7%、1.7%、3.5%,P>0.05)。结论西罗莫司洗脱支架和金属裸支架在冠心病患者中应用的远期安全性相似。
Objective To compare the long-term safety between sirolimus-eluting stent （SES） and bare-metal stent （BMS） in treatment of coronary heart disease. Methods In Beijing An Zhen Hospital,505 patients with coronary heart disease who underwent BMS between January 2000 and August 2004 were selected for retrospective comparison with 984 patients who underwent SES between January 2004 and January 2005. Mortality, stent thrombosis and non-fatal myocardial infarction during 2-year follow up in both groups were compared. Results There were no statistical differences in ratios of smoking, hypertensive dsease, hyperlipemia and diabetes, and also in the number of branches with coronary artery disease between the two groups. Patients in SES group were elder in average,and were with a higher rate of bifurcation lesions, a smaller mean stent diameter and a longer mean stent length than those of BMS group. During the 2-year follow-up, no significant differences were observed in survival rate, stent thrombosis, non-fatal myocardial infarction and death/non-fatal myocardial infarction between two groups （ 99. 3 %, 1.3 %, 1.1%, 1.8 % vs 98.3 %, 1.7 %, 1.7% ,3.5 %, respectively）. Conclusion The long-term safety of SES appeared comparable with BMS in patients with coronary artery disease.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2010年第11期1004-1006,共3页
Chinese Journal of Practical Internal Medicine
