摘要
目的探讨急性肝炎患者肝组织中庚型肝炎病毒（ＨＧＶ）的感染状况及其致病性。方法采用免疫组织化学方法对３７例血清学肝炎病毒标记甲～戊型均阴性的急性肝炎患者肝穿肝组织中的ＨＧＶＮＳ５抗原等进行检测，并对ＨＧＶ感染的致病性进行研究。结果ＨＧＶＮＳ５抗原的检出率为３７．８％（１４／３７），其中ＨＧＶＮＳ５单项阳性４例（急性庚型肝炎组），同时乙型肝炎表面抗原（ＨＢｓＡｇ）或（和）丙型肝炎病毒（ＨＣＶ）ＮＳ３抗原和（或）ＥＢ病毒抗原阳性表达１０例（庚型肝炎重叠感染组）；余２３例中７例ＨＢｓＡｇ阳性（急性乙型肝炎组），１６例上述抗原均阴性（非甲～庚型肝炎组）。４组间Ｆａｓ抗原检出例数、组织学活动指数、血清丙氨酸转氨酶及总胆红素在统计学上差异均无显著性。结论急性庚型肝炎时，肝损伤的程度与其他类型急性肝炎类同，ＨＧＶ感染对于急性肝炎的发病似可能有一定的作用。
Objective To study the infection due to hepatitis G virus (HGV) in liver tissues of patients with acute hepatitis and to investigate its pathogenicity. Methods HGV NS5 antigen was detected by using immunohistochemical method in the liver biopsy tissues of patients with acute hepatitis but serologically negative to hepatitis virus antigens from A to E. The clinical and pathological data were also analysed. Results 37 samples were tested, HGV NS5 antigen was detected in 14 (37.8%). 4 of the 14 were positive for HGV NS5 antigen alone (acute hepatitis G group) and 10 other cases were also positive for HBsAg, hepatitis C virus (HCV) NS3 antigen or EB virus antigen (superinfection group ). 7 cases were HBsAg positive alone(acute hepatitis B group) and the remaining 16 cases were negetive for all the antigens mentioned above ( non A～G hepatitis group). There was no difference among the 4 groups in the detecting rate of Fas antigen, histological activity index (HAI),serum alanine transferase(ALT) and total bilirubin (TBil). Conclusion It is suggested that HGV appears to play some role in the pathogenesis of acute viral hepatitis and the degree of liver injury in acute hepatitis G may be as severe as that of hepatitis caused by other types of viruses.
出处
《中华内科杂志》
CAS
CSCD
北大核心
1999年第4期245-247,共3页
Chinese Journal of Internal Medicine
关键词
病毒性肝炎
免疫组织化学
庚型肝炎病毒
Hepatitis, viral, human Immunohistochemistry Hepatitis G virus
