摘要
目的:观察吗替麦考酚酯(MMF)联合小剂量激素治疗难治性肾病综合征(RNS)的疗效及安全性。方法:选择难治性患者43例。MMF起始剂量为1.0～1.5g/d,联合激素治疗3个月,减至0.5g/d维持治疗。观察显效时间,定期监测蛋白尿等生化指标及不良反应。结果:治疗8周时,蛋白尿明显下降,血清白蛋白显著上升,差异有统计学意义(P<0.01)。主要不良反应为一过性肝酶升高(2/43)、感染(3/43)、消化道症状(3/43)等。结论:MMF联合激素治疗RNS疗效明显,不良反应较轻,尤其是对肝、肾无毒性反应,使用安全,值得临床推广。
Objective To investigate the efficacy and safety of mycophenolate moftil（MMF） combined with small dosage hormone in the treatment of refractory nephritic syndrome.Method Forty-three cases with refractory nephritic syndrome were collected.The initial dosage of MMF was 1.0 ～ 1.5 g/d and a joint hormone therapy for 3 months.Results The urinary protein was reduced significantly,the level of serum albumin was elevated after 8 weeks＇treatment,and the differences was significant（P〈0.05）.The main adverse effects were transient hepatic malfunction in 2 cases,infection in 3 cases,gastrointestinal tract symptom in 3 cases.Conclusion MMF combince with hormone shows remark effects in the treatment of refractory nephritic syndrome,with fewer adverse effects,especially with non-toxicity in liver and kidney.
出处
《吉林医学》
CAS
2010年第28期4875-4876,共2页
Jilin Medical Journal
